A study of a urine test to help diagnose bladder cancer that has come back (ARQUER)

Cancer type:

Bladder cancer

Status:

Open

Phase:

Other

This study wants to find out whether a urine test called MCM5 ELISA can help to diagnose bladder cancer that has come back after treatment (recurrent bladder cancer).

It is for people who have had bladder cancer or a recurrence in the past 2 years. 

More about this trial

After treatment for bladder cancer, you have regular follow up appointments. Your doctor checks how you are and looks for signs of bladder cancer coming back. During the appointments, you might have a test to look inside your bladder called a cystoscopy

Doctors are trying to find easier ways to look for signs of bladder cancer coming back. In this trial, they are looking at a urine test called MCM5 ELISA. 

The test looks for a protein called MCM5 in the urine. Doctors think that measuring the level of this protein can help to diagnose recurrent bladder cancer. 

Everyone taking part in this study gives a sample of urine when they are at the hospital before having a cystoscopy. 

The main aim of this trial is to find out whether the MCM5 ELISA test can help to diagnose recurrent bladder cancer. 

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 
 
Who can take part
You may be able to join this study if all of the following apply. You:
  • were diagnosed with bladder cancer in the last 2 years  
  • are going to have cystoscopies to look for signs of recurrent bladder cancer
  • can give urine samples 
  • are at least 18 years old 
Who can’t take part
You cannot join this study if any of these apply. You:
  • are having treatment for bladder cancer such as chemotherapy or radiotherapy 
  • have kidney or bladder stones 
  • have had prostate or kidney cancer
  • have had any medical procedure in your urinary system Open a glossary item in the past 2 weeks
  • have an infection in your prostate (prostatitis) 

Trial design

The study team hope that up to 320 people will agree to take part in this study. 

Everyone taking part in this study gives urine samples. You give a sample each time you are at the hospital having a cystoscopy. 

To have a cystoscopy, your doctor gently passes a flexible tube into your bladder. The tube has a light and an eyepiece at one end, so the doctor can see the inside of your bladder and the tube where your urine comes out (urethra).

How often you have a cystoscopy depends on your individual needs. Your doctor can tell you more about what happens during a cystoscopy and how often you have them. 

Hospital visits

You will not have any extra hospital visits as part of this study. You give the urine samples when you are at the hospital having cystoscopies.

Side effects

There are no side effects from having the MCM5 ELISA urine test. 

You may have some side effects from having a cystoscopy. Your doctor will tell you about all the possible risks before you have the test. 

We have information about cystoscopy and possible risks of having one

Location

Barnsley
Carlisle
Dundee
Harlow
London
Mansfield
Middlesbrough
Newcastle upon Tyne
Scunthorpe
Southampton
Stockton-on-Tees
Sunderland
Wakefield
Whitehaven
York

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Jacqueline Stockley 

Supported by

Arquer Diagnostics Ltd

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

15981

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

Rate this page:

No votes yet
Thank you!
We've recently made some changes to the site, tell us what you think