A study looking at biomarkers in bladder cancer (Gemtrans)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bladder cancer

Transitional cell cancer

Status:

Closed

Phase:

Other

This study is looking at chemicals and proteins called biomarkers in the blood and urine of people with bladder cancer.

Biomarkers are substances that doctors can measure in the body to help them tell how a disease is developing or how a treatment is working. In this study doctors want to look at biomarkers in people who are having gemcitabine and radiotherapy to treat bladder cancer. They call this combination of treatments GemX.

The aims of this study are

To find out more about biomarkers in people having GemX
To learn more about bladder cancer and its treatment

Who can enter

You may be able to enter this study if you are under the care of the Christie Hospital, Manchester and

You have transitional cell bladder cancer
Your doctor wants to treat you with gemcitabine and radiotherapy (GemX)
You have satisfactory blood test results
You are at least 18 years old

You cannot enter this study if you

Have had any other cancer, apart from carcinoma in situ of the cervix or non melanoma skin cancer that has been successfully treated
Have any other illness that is a cause for concern

Trial design

This study will recruit 50 people.

Everyone taking part will give weekly blood and urine samples while they have GemX treatment.

The study team will ask you to fill out a questionnaire at each visit during your treatment, again at 6 weeks and then at each of your yearly follow up visits, for 3 years. The questionnaire will ask about side effects and how you have been feeling. This is called a quality of life study.

If you agree to take part in this study, the researchers will also ask for a sample of tissue taken when you had surgery to diagnose your cancer. If you don’t want to give tissue samples for this study, you don’t have to. You can still take part in the study.

Hospital visits

There are no extra hospital visits if you take part in this study. The researchers will take the study samples when you come to the hospital to see the doctor.