A study looking at blood and urine samples to help diagnose and treat bile duct and pancreatic cancer (TRANSBIL)

Cancer type:

Bile duct cancer
Biliary tree cancers
Pancreatic cancer

Status:

Open

Phase:

Phase 2

In this study, doctors want to look at blood and urine samples from people who have symptoms similar to those with bile duct and pancreatic cancer. 

In most cases such symptoms are caused by other conditions. But it is important to make sure that those that are due to cancer, are diagnosed early. 

They hope the results of this study will help them develop new tests to diagnose bile duct and pancreatic cancer. And find new treatments.

More about this trial

 
Your GP arranges for you to see a specialist if you have symptoms that could be due to cancer that started in the bile ducts (cholangiocarcinoma) or pancreas. Possible symptoms of bile duct cancer and pancreatic cancer include:
  • tummy (abdominal) pain
  • a swollen tummy 
  • loss of appetite
  • weight loss 
  • jaundice (yellowing of the skin)
 
You may be referred to a team of doctors that specialises in problems of the gut (gastroenterology clinic). In some hospitals you, might see a specialist at a multidisciplinary diagnostic centre (MDC). These are centres for people with symptoms that could be due to cancer. 
 
Your specialist doctor may arrange for you to have tests such as a CT scan to look for the cause of your symptoms.
 
Doctors are always looking for better ways to diagnose and treat people with bile duct and pancreatic cancer. In this study, they want to look at blood and urine samples from people with symptoms that could be due to bile duct or pancreatic cancer. Doctors want to:
  • look for certain proteins (biomarkers)
  • find out why some people are more likely to develop bile duct and pancreatic cancer than others (genetic predisposition)
 

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 
 
You may be able to join this study if all of the following apply. You:
  • have symptoms that could be due to bile duct or pancreatic cancer
  • have been referred to the multidisciplinary diagnostic centre, gastroenterology clinic or endoscopy unit 
  • have a high risk of developing pancreatic cancer (your doctor can tell you more about this)  
  • are at least 18 years old

Trial design

This is a phase 2 study

Everyone taking part has a blood test and gives a urine sample. 

As part of your routine care, you may have a test to look at the inside of your tummy (abdomen). It might be an endoscopy, endoscopic ultrasound (EUS) Open a glossary item or an endoscopic retrograde cholangio pancreatography (ERCP). If you have one of these tests, your doctor might ask to take an extra tissue sample (biopsy Open a glossary item) during the test.  

The trial team will keep your blood, urine and tissue sample for up to 10 years. They might use it in future research studies. The information about you will be removed from the samples. So no one will be able to identify you.

Hospital visits

There are no extra hospital visits as part of this study. You have the blood test and give the urine sample during routine appointments at the hospital. 

Side effects

You should not have any side effects from taking part in this study.

Location

London

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Steve Pereira

Supported by

UCLH Cancer Collaborative
Pancreatic Cancer UK
Fiorina Pancreatic Cancer Fund (Royal Free Charity)
NIHR Clinical Research Network: North Thames

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

15401

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

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"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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