"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study following a group of men who have prostate cancer and it is known whether or not they have a change in the BRCA1 or BRCA2 gene (GENPROS)
This study is looking at whether there are differences in how well prostate cancer treatment works if you have changes to the BRCA1 or BRCA2 gene.
We know from research that men who have changes (
More about this trial
In this study, the researchers aim to follow up a group of men who have prostate cancer and who are known to have a mutation in the BRCA1 or BRCA2 gene. They will also follow up a group of men diagnosed with prostate cancer who are known not to have one of these gene changes. This is called a
You are unlikely to get any direct benefit from taking part in this study. But the researchers hope that the information they collect will show if there are differences in how likely the cancer is to grow and spread.
The long term aim is to improve their understanding of prostate cancer, meaning they will be able to give better advice about treatment.
Who can enter
You may be able to join this study if all of the following apply.
- You have been diagnosed with prostate cancer
- It is known whether or not you have changes (mutations) to genes called
- You are at least 18 years old
You cannot join this study if any of these apply.
- You have been diagnosed with prostate cancer while taking part in the IMPACT study
- It isn’t known whether or not you have changes to the BRCA1 or BRCA2 genes
The researchers need more than 1,000 men to join this study. If you agree to take part, you are giving the study team permission to look at your medical records. They will also ask for samples of your prostate cancer that are removed when you have a biopsy or surgery.
The study team will ask your doctors for an update on your treatment and how you are getting on every year. All the information collected about you is
The study team will ask you to give a sample of saliva or blood that they can use to study your DNA.
The researchers may look for inherited genes that could affect your risk of developing prostate cancer or how likely it is to grow and spread. There is a possibility that they may find information that could be relevant to you or your family’s medical care. If this happens, the study team may want to contact you. But when you agree to join the study, you can mark on the
You may need to make an extra visit to hospital to discuss the study and give your saliva or blood sample.
There are no side effects from taking part in this study.
How to join a clinical trial
Professor Ros Eeles
Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
Ronald and Rita McAulay Foundation
University of Cambridge