“I had treatment last year and I want to give something back.”
A study looking at the BRCA1 gene and the risk of developing breast cancer (AFFECT)
Coronavirus and cancer
We know it’s a worrying time for people with cancer, we have information to help. If you have symptoms of cancer contact your doctor.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study will collect information about changes in the BRCA1 gene and how they may affect the risk of developing breast cancer.
Doctors know that cancer is caused by changes to the cells in the body. These changes can happen when cells reproduce. All cells in the body have genes. When a cell reproduces, exact copies of the genes are made for each cell. Genes contain coded messages called
The BRCA1 gene is a gene that helps to repair DNA. Doctors know that some of the mutations in this gene can increase the risk of developing breast cancer. But there are many different mutations that can occur.
The aim of this study is to find out which mutations increase the risk of developing breast cancer, and which do not.
Please note that you are not likely to benefit from this study. But taking part may help others with breast cancer in the future.
Who can enter
You can enter this trial if you
- Have breast cancer with a change in the BRCA1 gene (but no change in the BRCA2 gene)
- Are at least 18 years old
You cannot enter this trial if you have a change in both the BRCA1 and
This study will recruit people when they attend the genetics clinic.
If you agree to take part, you will be asked about your family history of cancer. And you will give a blood sample. The trials office will contact you to find out where your surgery, or biopsy, was done. They will then request a small piece of tissue from the hospital.
The researchers will contact you by telephone, 2 and 5 years after your first contact, to ask about your general well being.
Taking part in this study does not involve any extra hospital visits.
You may have some discomfort or bruising in the area where the blood sample is taken. There are no other side effects associated with taking part in this study.
How to join a clinical trial
Dr Jo Morris
Breast Cancer Campaign
Guy's and St Thomas' NHS Foundation Trust
King's College London
NIHR Clinical Research Network: Cancer