A study looking at the BRCA1 gene and the risk of developing breast cancer (AFFECT)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Breast cancer





This study will collect information about changes in the BRCA1 gene and how they may affect the risk of developing breast cancer.

Doctors know that cancer is caused by changes to the cells in the body. These changes can happen when cells reproduce. All cells in the body have genes. When a cell reproduces, exact copies of the genes are made for each cell. Genes contain coded messages called DNA Open a glossary item. DNA can sometimes be damaged. If the DNA is not repaired it can cause a mutation Open a glossary item (change) in the gene. Some mutations are known to cause cancer.

The BRCA1 gene is a gene that helps to repair DNA. Doctors know that some of the mutations in this gene can increase the risk of developing breast cancer. But there are many different mutations that can occur.

The aim of this study is to find out which mutations increase the risk of developing breast cancer, and which do not.

Please note that you are not likely to benefit from this study. But taking part may help others with breast cancer in the future.

Who can enter

You can enter this trial if you

  • Have breast cancer with a change in the BRCA1 gene (but no change in the BRCA2 gene)
  • Are at least 18 years old

You cannot enter this trial if you have a change in both the BRCA1 and BRCA2 Open a glossary item genes.

Trial design

This study will recruit people when they attend the genetics clinic.

If you agree to take part, you will be asked about your family history of cancer. And you will give a blood sample. The trials office will contact you to find out where your surgery, or biopsy, was done. They will then request a small piece of tissue from the hospital.

The researchers will contact you by telephone, 2 and 5 years after your first contact, to ask about your general well being.

Hospital visits

Taking part in this study does not involve any extra hospital visits.

Side effects

You may have some discomfort or bruising in the area where the blood sample is taken. There are no other side effects associated with taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Jo Morris

Supported by

Breast Cancer Campaign
Guy's and St Thomas' NHS Foundation Trust
King's College London
NIHR Clinical Research Network: Cancer

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 3969

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Caroline took part in a clinical trial for breast cancer

“I had treatment last year and I want to give something back.”

Last reviewed:

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