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11 Sep 2019 19:24


My partner is currently being treated for recurrent cervical cancer.She has had three cycles of Avastin,Taxol and Carboplatin.For the fourth cycle the Hospital where she is being treated have decided to give Avastin the day before the Taxol and Carboplatin are given.

i have questioned this with he hospital as it’s my understanding that these three drugs have to be given on the same day for effective treatment.

can anyone shed any light on this or if they heard of this happening anywhere else



12 Sep 2019 14:40 in response to kmpag48

Hello and thank you for posting a question. I am very sorry to learn that your partner has recurrent cervical cancer. This must be a difficult situation for you both.

I would like to help as clearly this is worrying you. But I am afraid that I cannot reliably answer your question.  The pharmodynamics (the study of how the body responds to drugs) and pharmacokinetics (how drugs pass through the body) are very specialist areas and as a nurse I only have limited knowledge of this. But it seems that Avastin has a long half life which means that it hangs around in the body for a long time. So it might not matter, but in truth I don't know.

I had a look at the medical literature and have not found any information to suggest that the treatment is going to be less effective if bevacizumab (Avastin) is given the day before chemotherapy,. But neither can I find any information to suggest that doing this won't cause harm either. So all I can suggest is that you ask the hospital precisely what their rationale for changing things is.   From what I have read it seems that in studies the drugs are often all given on the same day (day 1 of the cycle).  So this seems to be the most common way of doing it.

I am sorry as I realise that this reply will be disappointing. Do get back to us if you have any other questions.   If you would like to telephone the number to call is Freephone 0808 800 4040 and the lines are open from 9am till 5pm Monday to Friday.

Kind regards,