Cutting off the blood supply
University of Southampton
About Ali Tavassoli
Dr Ali Tavassoli and his team at the University of Southampton are searching for ways to stop tumours from growing a new blood supply and spreading to other parts of the body. Without a blood supply to provide oxygen and nutrients to cancer cells, tumours cannot grow beyond the size of a pinhead.
Dr Tavassoli is using powerful techniques to look for small molecules that stop two important proteins, known as HIF-1 or HIF-2, sticking to each other. When these HIF proteins interact they set off a chain of events that help tumours grow a blood supply. His group will use the small molecules they find to learn more about the role of the HIF proteins in cancer cells, and to act as a springboard for the development of future anti-cancer drugs.
This work could lead to better ways to stop tumours growing and spreading round the body in the future.
Other research projects by Ali Tavassoli
Probing and targeting hypoxic response networks in tumorigenesis with small molecules: towards the next generation of healthcare
Funding period: 01 July 2009 to 30 June 2014
Deciphering interactions used by the influenza virus NS1 protein to silence the host antiviral sensor protein RIG-I using a bacterial reverse two-hybrid system
Mol Biosyst.2011;7 :1042-1045
Targeting tumor angiogenesis with small molecule inhibitors of hypoxia inducible factor
Chem Soc Rev.2011;: