Cancer Research UK on Google+ Cancer Research UK on Facebook Cancer Research UK on Twitter
 

Adrian Harris

Researcher Adrian Harris profile image

Targeting a cancer's blood supply

University of Oxford
John Radcliffe Hospital
Headley Way
Oxford
OX3 9DS
United Kingdom

Email: adrian.harris@oncology.ox.ac.uk
Tel: 01865 222 457
Web: Lab website

All cancers need to develop their own blood supply in order to keep growing. Professor Adrian Harris' research group based at the Weatherall Institute for Molecular Medicine is studying this process of new blood vessel growth, called angiogenesis, in great detail. 

Using this knowledge, they are developing ways to block angiogenesis and starve cancer cells of essential nutrients and oxygen. Professor Harris is a leading researcher in this field and is also running clinical trials to study new anti-angiogenesis drugs in people with cancer.

Listen to a short interview with Professor Harris about his research:

Full summary…
Understanding new pathways of tumour angiogenesis and how they relate to resistance to current therapies will provide new targets for therapy. Understanding how cancer cells adjust to a high stress environment, gives Professor Harris and his group the opportunity to use synthetic lethal approaches for therapy, which should have low normal tissue toxicity.
Full scientific summary…

Other research projects by Adrian Harris

Role of notch signalling and hypoxia in resistance to anti-angiogenic therapy
Funding period: 01 October 2010 to 30 September 2015

Funding period: 01 May 2010 to 30 April 2013

Publications


Impact of Exploratory Biomarkers on the Treatment Effect of Bevacizumab in Metastatic Breast Cancer

Clin Cancer Res.2011;17 :372-381

Human endothelial stem/progenitor cells, angiogenic factors and vascular repair

J R Soc Interface.2010;7 :S731-S751

More publications…