University College London
Paul O'Gorman Building
72 Huntley Street
About Sergio Quezada
Dr Sergio Quezeda and his colleagues at University College London are studying why the body’s immune response, which fights ‘foreign invaders’ such as viruses and bacteria, often fails to recognise and kill dangerous cancer cells.
Dr Quezeda is focusing on a type of immune cell that helps drive an effective immune response, called a T helper cell. He wants to know how T helper cells are controlled as tumours grow and what stops them recognising cancer cells as dangerous. From this work, he hopes to discover how T helper cells might be harnessed to trigger an immune response against tumours.
Understanding more about how these key immune cells work might lead to new ways to boost the immune response to target and destroy cancer cells.
Other research projects by Sergio Quezada
Defining the mechanisms underpinning the function of regulatory and effector tumour-reactive CD4+ T cells during tumorigenesis: applications to cancer immunotherapy
Funding period: 01 November 2010 to 31 October 2016
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
Immunol Rev.2011;241 :104-118
Ipilimumab attenuation of an inhibitory immune checkpoint improves survival in metastatic melanoma
Expert Rev Anticancer Ther.2010;10 :1697-1701