Killing myeloma cells with toxic waste
About Holger Auner
His research is focusing on a process called the protein degradation pathway that acts like a waste disposal system, helping myeloma cells get rid of unwanted or faulty molecules. Blocking this process in myeloma cells grown in the lab causes a toxic build-up of molecules that cells simply can’t cope with, leading to the cancer cells dying. Dr Auner wants to reproduce this effect in patients, so he’s analysing different parts of the protein degradation pathway to find targets that can be switched off by drugs.
Myeloma can be a real challenge to treat, so research like this is urgently needed to help keep myeloma patients with their families for longer.
Other research projects by Holger Auner
Funding period: 01 August 2012 to 31 July 2016