Holger Auner : Cancer Research UK
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Holger Auner

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Killing myeloma cells with toxic waste

Imperial College London
Hammersmith Hospital Campus
Du Cane Road
W12 0NN
United Kingdom

Email: holger.auner04@imperial.ac.uk
Tel: 02083834017
Web: Lab website

About Holger Auner

In London’s Imperial College, Dr Holger Auner is finding new ways to treat multiple myeloma, a cancer affecting special immune cells in the bone marrow known as plasma cells.

His research is focusing on a process called the protein degradation pathway that acts like a waste disposal system, helping myeloma cells get rid of unwanted or faulty molecules. Blocking this process in myeloma cells grown in the lab causes a toxic build-up of molecules that cells simply can’t cope with, leading to the cancer cells dying. Dr Auner wants to reproduce this effect in patients, so he’s analysing different parts of the protein degradation pathway to find targets that can be switched off by drugs.


Myeloma can be a real challenge to treat, so research like this is urgently needed to help keep myeloma patients with their families for longer.

Other research projects by Holger Auner

Clinician Scientist Fellowship
Funding period: 01 August 2012 to 31 July 2016