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David Lane

David Lane profile image

Queen Mary, University of London
College of Life Sciences
Dow Street
Dundee
DD1 5EH
United Kingdom

Email: d.p.lane@dundee.ac.uk

Using molecular knowledge of cancer to develop new treatments

 

Professor Sir David Lane is one of the world's leading cancer researchers, and was Cancer Research UK's first Chief Scientist from 2007 until 2010. His work has been funded by the charity for more than 30 years, and in 1979 he discovered the p53 protein, which plays a central role in preventing cancer. He and his team are now investigating ways to turn our knowledge about the molecules involved in cancer - including p53 - into life-saving treatments for the disease. Professor Lane has won many international prizes and awards for his outstanding work in this field.

 

Watch an interview with Professor Lane, as he talks about the discovery of p53 and its importance for cancer research and potential future treatments:

 

Full summary…
The elucidation of the p53 and Rb pathways, which are aberrant in most cancers, has provided many new targets for drug development. In many tumours the wild type p53 gene remains intact but its function is compromised by loss of upstream signalling pathways or downstream effectors.
Full scientific summary…

Other research projects by David Lane

Pre-clinical studies on the use of novel small-molecule sirtuin inhibitors for the treatment of HPV-associated neoplasias
Funding period: 01 October 2008 to 31 December 2012

Biological Sciences Committee (BSC) Programme Grants
Funding period: 01 January 2007 to 31 October 2013

Publications


Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables

J Clin Oncol.2011;29 :1400-1407

A combined analysis of genome-wide association studies in breast cancer

Breast Cancer Res Treat.2011;126 :717-727

More publications…