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Alan Clarke

Researcher Alan Clarke profile image

Understanding how bowel cancer develops

Cardiff University
School of Biosciences
Biomedical Sciences Building
Cardiff University
Cardiff
CF10 3AX
United Kingdom

Email: clarkear@cf.ac.uk
Tel: 02920874609
Web: Lab website

Professor Alan Clarke at Cardiff University is studying how bowel cancer develops. His research focuses on the role of the APC gene, which is found to be faulty in many cases of bowel cancer. 

 

This important work could lead to improvements in diagnosis and treatment of this disease.

Full summary…
The principal interest of Professor Clarke and his laboratory lies in understanding the pathogenesis of disease, with specific focus on genes involved in the very early stages of divergence from normality.
Full scientific summary…

Other research projects by Alan Clarke

Investigating PI3 kinase and Ki-Ras pathway interactions in colorectal cancer: new models and drug validation.
Biological Sciences Committee (BSC) Project Grants
Funding period: 01 January 2010 to 31 December 2012

Validating methylation sensing proteins as therapeutic targets
Biological Sciences Committee (BSC) Project Grants
Funding period: 01 July 2008 to 30 June 2013

Biological Sciences Committee (BSC) Project Grants
Funding period: 01 January 2011 to 31 December 2013

Publications


LKB1 loss of function studied in vivo

FEBS Lett.2011;585 :958-966

Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB.

Gut.2011;:

More publications…