Reawakening silent genes to treat neuroblastoma
University of Bristol
School of Medical Sciences
Web: Lab website
About Karim Malik
Dr Karim Malik from the University of Bristol is leading a team looking at improving treatment for neuroblastoma, a type of cancer caused by nerve tissue left over from when a baby is growing in the womb. Neuroblastoma is one of the commonest childhood cancers after leukaemia and it can be hard to treat effectively with current therapies.
Neuroblastoma can start when key genes in cells are switched off by special chemical ‘tags’, a process known as epigenetic modification. Dr Malik is cataloguing all these chemical tags in neuroblastoma cells, and finding out whether any abnormal tags can be removed using drugs. He hopes that this approach will reactivate silenced genes and prevent cancer cells from growing, which could bring hope of new treatments for children with this cancer.
Other research projects by Karim Malik
Funding period: 01 July 2011 to 30 June 2014