Dr John Le Quesne

Finding a cancer bottleneck

Dr John Le Quesne, based at the MRC Toxicology Unit in Leicester, is part of a large project which will improve our understanding of how cancers grow. The researchers are looking at how tumour cells interact with cells around them. They’re investigating how the interactions might kickstart the genes that cause tumours to grow and spread.

The team are investigating a protein called eIF4A, which activates certain cancer genes. Dr Le Quesne is an expert in these sorts of proteins, and will be adding his expertise to the project. 

There are two versions of this protein: eIF4A1 and eIF4A2. These proteins are important in activating genes in cancer cells, and neighbouring normal cells in the tumour. But the two proteins have very different functions. eIF4A1 is associated with a poor outcome  and it seems to lead to tumours growing quickly. eIF4A2 stops this fast growth, and is associated with a better outcome for patients.

The researchers think that eIF4A is an important a ‘bottleneck’ for cell processes. They believe that many cancer-causing genes depend on this protein, and that targeting it may treat cancer in a new, specific and effective way.

Cancer biology

MRC Toxicology Unit, University of Leicester 

Email: jlq2@le.ac.uk

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