Liver cancer mortality statistics

Deaths

Deaths from liver cancer, 2014, UK

 

Proportion of all deaths

Percentage liver cancer is of total cancer deaths, 2014, UK

 

Age

Peak rate of liver cancer deaths, 2012-2014, UK

 

Liver cancer is the ninth most common cause of cancer death in the UK (2014), accounting for 3% of all cancer deaths.[1-3] In males, it is the seventh most common cause of cancer death in the UK (4% of all male cancer deaths), whilst it is the 10th most common cause of cancer death in females in the UK (3% of all female cancer deaths).[1-3]

In 2014, there were 5,091 liver cancer deaths in the UK: 3,055 (60%) in males and 2,036 (40%) in females, giving a male:female ratio of around 15:10.[1-3] The crude mortality rate Open a glossary item shows that there are 10 liver cancer deaths for every 100,000 males in the UK, and 6 for every 100,000 females.

The European age-standardised mortality rates Open a glossary item (AS rates) are significantly higher in Wales and Scotland compared with England for males only. There are no significant differences between the other constituent countries of the UK for either sex.[1-3]

Liver Cancer (C22), Number of Deaths, Crude and European Age-Standardised (AS) Mortality Rates per 100,000 population, UK, 2014

England Wales Scotland Northern Ireland UK
Male Deaths 2,447 193 338 77 3,055
Crude Rate 9.1 12.7 13.0 8.5 9.6
AS Rate 11.1 13.6 15.6 11.8 11.6
AS Rate - 95% LCL 10.7 11.7 13.9 9.2 11.2
AS Rate - 95% UCL 11.6 15.5 17.3 14.5 12.1
Female Deaths 1,695 97 197 47 2,036
Crude Rate 6.2 6.2 7.2 5.0 6.2
AS Rate 6.2 5.6 7.0 5.7 6.2
AS Rate - 95% LCL 5.9 4.5 6.0 4.0 5.9
AS Rate - 95% UCL 6.5 6.7 7.9 7.3 6.5
Persons Deaths 4,142 290 535 124 5,091
Crude Rate 7.6 9.4 10.0 6.7 7.9
AS Rate 8.4 9.2 10.7 8.3 8.7
AS Rate - 95% LCL 8.2 8.2 9.8 6.8 8.4
AS Rate - 95% UCL 8.7 10.3 11.6 9.8 8.9

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

Liver cancer mortality rates vary significantly throughout the UK between health boundaries for both males and females, with the highest rates in parts of Northern England and inner city London, and the lowest rates in Southern England and parts of Wales.[4]

References

  1. Data were provided by the Office for National Statistics on request, November 2015. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregistrationsummarytables/previousReleases.
  2. Data were provided by Information Services Division (ISD) Scotland on request, November 2015. Similar data can be found here: http://www.nrscotland.gov.uk/statistics-and-data/statistics/statistics-by-theme/vital-events/vital-events-reference-tables.
  3. Data were provided by the Northern Ireland Statistics and Research Agency on request, November 2015. Similar data can be found here: http://www.nisra.gov.uk/demography/default.asp2.htm.
  4. Liver cancer (C22) European age-standardised mortality rates by UK Health Boundaries, 2009-2011. These data were extracted from the UK Cancer Information Service, version 4.5b 001 on 17/10/2013.
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Liver cancer mortality is strongly related to age, with the highest mortality rates being in older males and females. In the UK in 2012-2014, on average each year around half (49%) of deaths were in people aged 75 and over.[1-3]

Age-specific mortality rates rise gradually from around age 45-49, and then more sharply from around age 60-64, with the highest rates in the 85-89 age group. Mortality rates are significantly higher for males than for females in those aged 45-49 and over and this gap is widest at the ages of 60-64, when the male:female ratio of age-specific rates (to account for the different proportions of males to females in each age group) is around 23:10.[1-3]

Liver Cancer (C22), Average Number of Deaths per Year and Age-Specific Mortality Rates, UK, 2012-2014

For most cancer types, mortality by age largely reflects incidence and survival by age, e.g. typically, higher incidence and lower survival in older people results in higher mortality in older people.

References

  1. Data were provided by the Office for National Statistics on request, November 2015. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregistrationsummarytables/previousReleases.
  2. Data were provided by the Information Services Division (ISD) Scotland on request, November 2015. Similar data can be found here: http://www.nrscotland.gov.uk/statistics-and-data/statistics/statistics-by-theme/vital-events/vital-events-reference-tables.
  3. Data were provided by the Northern Ireland Statistics and Research Agency on request, November 2015.Similar data can be found here: http://www.nisra.gov.uk/demography/default.asp2.htm.
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Liver cancer mortality rates have increased overall in the UK since the early 1970s.[1-3] For males, European age-standardised Open a glossary item (AS) mortality rates increased more than three-fold between 1971-1973 and 2010-2012. The rise is bigger for females, with rates increasing more than four-fold between 1971-1973 and 2010-2012. Over the last decade (between 2001-2003 and 2010-2012), European AS mortality rates have increased by 44% and 50% in males and females, respectively. The increase in liver cancer mortality rates reflects the increase in incidence rates. There are likely to be several reasons for this, including increasing past prevalence of major risk factors such as heavy alcohol consumption and infection with the hepatitis B and C viruses.[4,5]

Liver Cancer (C22), European Age-Standardised Mortality Rates, UK, 1971-2012

Liver cancer mortality rates have increased overall for all of the broad age groups in the UK since the early 1970s.[1-3] The largest increases have been in people aged 80+, with European AS mortality rates increasing nearly eight-fold between 1971-1973 and 2010-2012. These patterns closely reflect the increase in liver cancer incidence rates by age.

Liver Cancer (C22), European Age-Standardised Mortality Rates, By Age, UK, 1971-2012

References

  1. Data were provided by the Office for National Statistics on request, January 2014. Similar data can be found here: http://www.ons.gov.uk/ons/publications/all-releases.html?definition=tcm%3A77-27475.
  2. Data were provided by ISD Scotland on request, March 2014. Similar data can be found here: http://gro-scotland.gov.uk/statistics/theme/vital-events/general/ref-tables/index.html.
  3. Data were provided by the Northern Ireland Cancer Registry on request, December 2013. Similar data can be found here: http://www.nisra.gov.uk/demography/default.asp22.htm.
  4. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.
  5. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
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Liver cancer is the 7th most common cause of cancer death in Europe, with around 62,200 deaths from liver cancer in 2012 (4% of the total). In Europe (2012), the highest World age-standardised Open a glossary item mortality rates for liver cancer are in the Republic of Moldova for both men and women; the lowest rates are in Norway for men and Belarus for women. UK liver cancer mortality rates are estimated to be the 11th lowest in males in Europe, and 17th lowest in females.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Liver cancer is the 2nd most common cause of cancer death worldwide, with more than 745,000 deaths from liver cancer in 2012 (9% of the total). Liver cancer mortality rates are highest in Eastern Asia and lowest in South Central Asia, but this partly reflects varying data quality worldwide.[1]

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
  2. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.
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There is evidence for a strong association between liver cancer mortality and deprivation for both males and females in England.[1] England-wide data for 2007-2011 show European age-standardised Open a glossary item mortality rates are 100% higher for males living in the most deprived areas compared with the least deprived, and 72% higher for females.[1]

Liver Cancer (C22), European Age-Standardised Mortality Rates by Deprivation Quintile, England, 2007-2011

The estimated deprivation gradient in liver cancer mortality between people living in the most and least deprived areas in England has not changed in the period 2002-2011.[1] It has been estimated that there would have been around 600 fewer cancer deaths each year in England during 2007-2011 if all people experienced the same mortality rates as the least deprived.[1]

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Cancer Statistics Explained

See information and explanations on terminology used for statistics and reporting of cancer, and the methods used to calculate some of our statistics.

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