Cancer of unknown primary mortality statistics

Deaths

Deaths from cancer of unknown primary, 2016, UK.

Percentage of all deaths

Percentage cancer of unknown primary contributes to total cancer deaths, 2016, UK

Age

Peak rate of cancer of unknown primary deaths, 2012-2014, UK

 

Trend over time

Change in cancer of unknown primary mortality rates since the early 1970s, UK

Cancer of unknown primary is the 5th most common cause of cancer death in the UK, accounting for 6% of all cancer deaths (2016).[1-3]

In males in the UK, cancer of unknown primary is the 6th most common cause of cancer death (5% of all male cancer deaths). In females in the UK it is the 4th most common cause of cancer death (6% of all female cancer deaths).

47% of cancer of unknown primary deaths in the UK are in males, and 53% are in females.

Cancer of unknown primary mortality rates (European age-standardised (AS) rates Open a glossary item ) for persons are significantly higher than the UK average in Wales, and similar to the UK average in all other UK constituent countries.

Cancer Of Unknown Primary (C77-C80), Number of Deaths, Crude and European Age-Standardised (AS) Mortality Rates per 100,000 Population, UK, 2016

  England Scotland Wales Northern Ireland UK
Male Deaths 3674 362 290 107 4433
Crude Rate 13.5 13.8 18.9 11.7 13.7
AS Rate 16.7 16.9 20.8 16.6 16.9
AS Rate - 95% LCL 16.2 15.1 18.4 13.5 16.4
AS Rate - 95% UCL 17.2 18.6 23.2 19.8 17.4
Female Deaths 4151 406 314 106 4977
Crude Rate 14.8 14.6 19.9 11.2 15.0
AS Rate 14.5 14.0 17.8 11.9 14.6
AS Rate - 95% LCL 14.0 12.6 15.8 9.6 14.1
AS Rate - 95% UCL 14.9 15.4 19.7 14.1 15.0
Persons Deaths 7825 768 604 213 9410
Crude Rate 14.2 14.2 19.4 11.4 14.3
AS Rate 15.4 15.1 19.0 13.7 15.5
AS Rate - 95% LCL 15.1 14.1 17.5 11.9 15.2
AS Rate - 95% UCL 15.7 16.2 20.5 15.6 15.8

95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate
 

For cancer of unknown primary mortality differences between countries largely reflect differences in incidence.

References

  1. Data were provided by the Office for National Statistics on request, October 2017. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Northern Ireland Cancer Registry on request, December 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016, ICD-10 C77-C80.

Last reviewed:

Cancer of unknown primary mortality is strongly related to age, with the highest mortality rates being in older people. In the UK in 2014-2016, on average each year 6 in 10 (60%) deaths were in people aged 75 and over.[1-3] This largely reflects higher incidence and lower survival for cancer of unknown primary in older people.

Age-specific mortality rates rise steadily from around age 40-44 and more steeply from around age 65-69. The highest rates are in the 90+ age group for males and females.

Mortality rates are significantly higher in males than females in a number of (mainly older) age groups. The gap is widest at age 90+, when the age-specific mortality rate is 1.4 times higher in males than females.

Cancer Of Unknown Primary (C77-C80), Average Number of Deaths per Year and Age-Specific Mortality Rates per 100,000 Population, UK, 2014-2016

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

References

  1. Data were provided by the Office for National Statistics on request, October 2017. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Northern Ireland Cancer Registry on request, December 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2014-2016, ICD-10 C77-C80.

Last reviewed:

Cancer of Unknown Primary European age-standardised (AS) Open a glossary item mortality rates for males and females combined increased by 88% in the UK between 1971-1973 and 2014-2016.[1-3] The increase was larger in females than in males.

For males, cancer of unknown primary AS mortality rates in the UK increased by 77% between 1971-1973 and 2014-2016. For females, cancer of unknown primary AS mortality rates in the UK increased by 97% between 1971-1973 and 2014-2016.

Over the last decade in the UK (between 2004-2006 and 2014-2016), cancer of unknown primary AS mortality rates for males and females combined decreased by 35%. In males AS mortality rates decreased by 37%, and in females rates decreased by 33%.

Cancer of Unknown Primary (C77-C80), European Age-Standardised Mortality Rates per 100,000 Population, UK, 1971-2016

For most cancer types, mortality trends largely reflect incidence and survival trends. For example, rising mortality may reflect rising incidence and stable survival, while falling mortality may reflect rising incidence and rising survival.

Cancer of Unknown Primary mortality rates have increased overall in most broad adult age groups in males and females combined in the UK since the early 1970s, but have remained stable in some.[1-3] Rates in 25-49s have increased by 15%, in 50-59s have remained stable, in 60-69s have increased by 30%, in 70-79s have increased by 77%, and in 80+s have increased by 208%.

Cancer of Unknown Primary (C77-C80), European Age-Standardised Mortality Rates per 100,000 Population, By Age, UK, 1971-2016

References

  1. Data were provided by the Office for National Statistics on request, October 2017. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Northern Ireland Cancer Registry on request, December 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1971-2016, ICD-10 C77-C80.

Last reviewed:

There is evidence for an association between cancer of unkown primary (CUP) mortality and deprivation for both males and females in England.[1] England-wide data for 2007-2011 show European age-standardised Open a glossary item mortality rates are 76% higher for males living in the most deprived areas compared with the least deprived, and 61% higher for females.[1]

Cancer of Unknown Primary (C77-C80), European Age-Standardised Mortality Rates by Deprivation Quintile, England, 2007-2011

The estimated deprivation gradient in CUP mortality between people living in the most and least deprived areas in England has not changed in the period 2002-2011.[1] It has been estimated that there would have been around 1,700 fewer cancer deaths each year in England during 2007-2011 if all people experienced the same mortality rates as the least deprived.[1]

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for: UK, 2007-2011, ICD-10 C77-C80

Deprivation gradient statistics were calculated using mortality data for 2007-2011. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

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