Cancer's toughest challenges

We're seeking investigators from any country, working in any discipline to come together and tackle some of the biggest barriers to progress.

Tissue Specificity Grand Challenge

Tissue Specificity 

Devise approaches to prevent or treat cancer based on mechanisms that determine tissue specificity of some cancer genes                                                                                        

Cancer vaccinology Grand Challenge

Tumour Vaccinology

Create novel tumour vaccinology approaches that establish or enhance successful immune responses beyond what is revealed by current checkpoint therapy

Treatment Regimens Grand Challenge

Treatment Regimens

Define mechanistic rules for combinatorial treatments to overcome resistance and avoid toxicity


Dormancy Grand Challenge


Identify and target tumour cells that remain dormant for many years after seemingly effective treatment



Lethal non-lethal Grand Challenge

Lethal vs non-lethal 

Distinguish between lethal cancers which need treating, and non-lethal cancers that don’t


Deep Learning Grand Challenge

Artificial Intelligence 

Detect cancer earlier by interrogating medical and non-medical data sets using machine and deep-learning


Microbiota Grand Challenge


Improve treatment responses by manipulating the composition and status of the microbiota                                        


Cancer Causes Grand Challenge

Cancer Causes

Determine the mechanisms that cause cancer without known mutagenesis, such as obesity, in order to devise novel interventions

Our role in beating cancer globally

Cancer Research UK is the largest independent funder of cancer research in the world. Find out more about how we're beating cancer sooner on a global scale


  • Any country
  • Any discipline
  • Any academic institution or commercial entity
  • Any career stage

Initial questionnaire deadline: 14 September 2017

Get in touch

lucy shaw

If you wish to discuss your proposal or have any questions around the scheme please contact Dr Lucy Shaw by emailing

For help with our online grants system eGMS, please contact grants helpline on 0203 469 5452 or

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