Read article A study to understand more about why chemotherapy to treat lung cancer can stop working (CHEMORES)
This study will look for changes in blood and tissue samples before and after chemotherapy for lung cancer, to try to find out how cancer cells stop themselves being harmed by chemotherapy.
Doctors may use surgery, radiotherapy, or chemotherapy to treat lung cancer. Your treatment will depend on your type and stage of lung cancer. If you have non small cell lung cancer, you may have a combination of these. If you have small cell lung cancer, you would usually have chemotherapy.
We know from research that cancer cells can become ‘resistant’ to treatment. In lung cancer for example, cancer cells can sometimes reduce the concentration of the drug inside them, and repair DNA damage.
Understanding why resistance happens will help develop improved treatment for lung cancer. This study is looking at genes and proteins in the blood and cancer tissue of people having lung cancer chemotherapy containing platinum drugs. The main aim of this study is to find out why lung cancer often becomes resistant to treatment.
You will not get any direct benefit from taking part in this study, and it will not change your treatment in any way. But the results of the study will be used to help people with cancer in the future.
Recruitment
Phase
Who can enter
You can enter this study if you
- Have small cell lung cancer, or non small cell lung cancer that is stage 3 or 4
- Are due to have chemotherapy containing a platinum drug, for example cisplatin or carboplatin
- Have had a small sample of cancer tissue (a biopsy) removed from your lung, or you would be willing to have some tissue removed if appropriate
- Are well enough to take part
You cannot enter this study if you
- Are having treatment as part of a clinical trial (if your trial team are happy for you to also take part in this study, you can still take part)
- Are due to start a course of combined chemotherapy and radiotherapy (‘chemoradiation’)
Trial design
This study will recruit up to 1,200 people. Everyone will give a blood sample (between 2 and 4 teaspoons) and permission for the study team to
- Use a sample of stored tissue taken from a previous biopsy
- Take information from your hospital notes, including about your disease and treatment
- Send the samples to be studied by other member of the research team in Europe
You do not have to join the next part of the study if you don’t want to. If you would like to, you will
- Give another 4 teaspoons of blood
- Give one or more samples of cancer tissue, (biopsy) or fluid from your cancer tissue (fine needle aspirate) if your cancer can be easily reached to do this
The study team will look at these samples to find out how genes and proteins in cancer tissue change after chemotherapy. They will then check these findings against results from the stored samples and medical information.
Throughout the study you will remain under the care of your regular cancer specialist.
Hospital visits
Where possible, you will give your study blood samples at the same time as your routine blood samples.
If you give any extra biopsies or fine needle aspirates, you may need to make extra hospitals visits to the Christie Hospital in Manchester. The samples would be taken before and after one cycle of chemotherapy, and if your cancer comes back. The study team will tell you about any hospital visits you have to make.
Side effects
You may have a small bruise where you gave your blood sample.
If you have biopsies for the study, the side effects will depend on the type of biopsy you have. You may have
- Pain or discomfort at the biopsy site (you will have local anaesthetic to help reduce this)
- Bleeding
- Bruising
- Sore throat (if you have a biopsy taken during a bronchoscopy)
Location of trial
For more information
Please note: we cannot help you to join a specific trial. Unless we state otherwise in this trial summary, you need to print this page and take it to your own doctor to discuss.
Find out how to join a trial or contact our cancer information nurses for other questions about cancer by phone (0808 800 4040), by email, or at
Cancer Research UK
Angel Building
407 St John Street
London
EC1V 4AD
Chief Investigator
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How to take part
Read more about how to join a clinical trial
