Cancer growth blockers
This page is about cancer growth blockers (also called cancer growth inhibitors). They are a type of biological therapy and include tyrosine kinase inhibitors, proteasome inhibitors, mTOR inhibitors, PI3K inhibitors, histone deacetylase inhibitors and hedgehog pathway blockers. You can find information about
About growth factors
Growth factors are natural body chemicals that control cell growth. There are many different types of growth factors. They work by plugging in to receptors on or in the cancer cell. This sends a signal in the cell, which sets off a chain of chemical reactions that make the cell grow and divide. These signalling systems are very complicated and sometimes different growth factors work together.
Cancer growth blockers
Cancer growth blockers are drugs that block growth factors, so they can slow or stop the growth of a cancer or shrink it. They are a type of biological therapy. They work in different ways by
- Lowering the amount of growth factors in the body
- Blocking the cancer cell receptors
- Blocking the signals inside the cell that tell it to divide and grow
Cancer growth blockers are named after the chemical that they block. They include tyrosine kinase inhibitors (TKI's), proteasome inhibitors, mTOR inhibitors, PI3K inhibitors, histone deacetylase inhibitors and hedgehog pathway blockers.
Growth factor blockers (inhibitors) are an exciting new way of treating cancer. Scientists are working on developing new inhibitors for different types of growth factors to treat different cancers.
General side effects
The side effects of cancer growth blockers depend on the particular drug that you have. But they can cause general side effects such as tiredness, diarrhoea, skin changes (such as rashes and a change in colour), a sore mouth, weakness and loss of appetite.
Growth factors are chemicals produced by the body that control cell growth. There are many different types of growth factors and they all work in different ways. Some tell cells what type of cells they should become (how they should specialise). Some make cells grow and divide into new cells. Some tell cells to stop growing or to die.
Growth factors work by plugging in to receptors on the cell surface. This sends a signal to the inside of the cell, which sets off a chain of complicated chemical reactions.
There are a number of different growth factors. Examples include
- Epidermal growth factor (EGF) – controls cell growth
- Vascular endothelial growth factor (VEGF) – controls blood vessel development
- Platelet derived endothelial growth factor (PDGF) – controls blood vessel development and cell growth
- Fibroblast growth factor(FGF) – controls cell growth
Each growth factor works by attaching to the corresponding receptor on the cell surface. For example, EGF binds to epidermal growth factor receptor (EGFR).
A cancer growth blocker blocks the growth factors that trigger the cancer cells to divide and grow. Scientists are looking at different ways of doing this such as
- Lowering levels of the growth factor in the body
- Blocking the growth factor receptor on the cancer cell
- Blocking the signals inside the cell that start up when the growth factor triggers the receptor
Most of these treatments work by blocking the signalling processes that cancer cells use to divide.
Cancer cells are often very sensitive to growth factors. So if we can block them, we can stop some types of cancer from growing and dividing. Scientists are developing different inhibitors for the different types of growth factors.
It isn’t easy to group biological therapies into different types because the groups often overlap. This can get very confusing. Some cancer growth blockers block blood vessel growth to the growing cancer (anti angiogenic drugs). Others are also monoclonal antibodies. We have more explanation about the different types of biological therapies in this section.
There are different types of cancer growth blockers. They can be grouped according to the types of chemical that they block. Some of the main types are
- Tyrosine kinase inhibitors
- Proteasome inhibitors
- mTOR inhibitors
- PI3K inhibitors
- Histone deacetylase inhibitors
- Hedgehog pathway blockers
Tyrosine kinase inhibitors are also called TKIs. They block chemical messengers (enzymes) called tyrosine kinases. Tyrosine kinases help to send growth signals in cells. So blocking them stops the cell growing and dividing. Cancer growth blockers can block one type of tyrosine kinase or more than one type. TKIs that block more than one type of tyrosine kinase are called multi-TKIs.
TKIs in use or in clinical trials include
- Axitinib (Inlyta)
- Dasatinib (Sprycel)
- Erlotinib (Tarceva)
- Gefitinib (Iressa)
- Imatinib (Glivec)
- Lapatinib (Tyverb)
- Nilotinib (Tasigna)
- Pazopanib (Votrient)
- Sorafenib (Nexavar)
- Sunitinib (Sutent)
The links above take you to more information about these drugs. You take these TKIs as tablets or capsules, usually once or twice a day.
Proteasomes are tiny, barrel shaped structures found in all cells. They help break down proteins that the cell doesn't need into smaller parts. The cell can then use them to make new proteins that it does need. Drug treatments that block proteasomes from working are called proteasome inhibitors. They cause a build up of unwanted proteins in the cell, which makes the cancer cells die.
Bortezomib (Velcade) is a proteasome inhibitor used to treat myeloma. You have it as an injection through a tube into a vein. There is information about bortezomib in the section about treating myeloma.
mTOR is a type of protein called a kinase protein. It can make cells produce chemicals such as cyclins that trigger cell growth. It may also make cells produce proteins that trigger the development of new blood vessels. Cancers need new blood vessels in order to grow.
In some types of cancer mTOR is switched on, which makes the cancer cells grow and produce new blood vessels. mTOR blockers (inhibitors) are a newer type of cancer growth blocker. They can stop the growth of some types of cancer. mTOR inhibitors include temsirolimus (Torisel), everolimus (Afinitor) and deforolimus.
PI3Ks are a group of closely related kinase proteins. Their full name is phospho inositide 3 kinases. They do a number of different things in cells. For example they act like switches in the cell – turning on other proteins such as mTOR (see above). Switching on PI3Ks may make cells grow and multiply, or trigger the development of blood vessels, or help cells to move around.
In some cancers PI3K is permanently switched on, which means that the cancer cells grow uncontrollably. Researchers are developing new treatments that block (inhibit) PI3K. They hope this will stop the cancer cells growing and make them die. This type of cancer growth blocker is only available within a clinical trial. It will be some time before we know how well it works in treating cancer.
Histone deacetylase inhibitors are also called HDAC inhibitors or HDIs. They block the action of a group of enzymes that remove chemicals called acetyl groups from particular proteins. This can stop cancer cells from growing and dividing and sometimes kills them completely.
HDACs are a newer type of cancer growth blocker. HDACs used in cancer treatment or in clinical trials include vorinostat (Zolinza), belinostat, panobinostat, entinostat and mocetinostat.
Hedgehog pathway blockers are drugs that target a group of proteins known as the hedgehog pathway. In the developing embryo, these proteins send signals that help cells to grow in the right place and in the right way. The hedgehog pathway can also control the growth of blood vessels and nerves. In adults, hedgehog pathway proteins are not usually active. But in some people, changes in a gene switch them on. Hedgehog pathway blockers are designed to switch off the proteins and stop the growth of the cancer.
This type of biological therapy is quite new. Vismodegib (Erivedge) is an example of a hedgehog pathway blocker being looked at in clinical trials.
All treatments can cause side effects. While there are general side effects for a type of treatment, they vary for each individual drug. In general, cancer growth blockers can cause
- Tiredness (fatigue)
- Skin changes, such as rashes or discolouration
- A sore mouth
- Loss of appetite
- Low blood counts
- Swelling of parts of the body, due to build up of fluid
Tell your doctor or nurse if you have any of these effects. You may be able to have medicines to help to control them.
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