Simple test predicts return of bladder cancer

British Journal of Cancer

Scientists have devised a simple test for an earlier and more accurate warning of returning bladder cancer than existing methods, according to research published in the British Journal of Cancer

"The TERT test is read by a machine which is simpler, more accurate and available to use straightaway." - Professor Alan Ruffion

Researchers from the University Hospital of Lyon tested the urine of 348 bladder cancer patients* for a faulty protein called TERT, and this was able to predict when the cancer was about to return in more than 80 per cent of patients. The standard method, called cytology, detected the return in only 34 per cent of patients.

The new test detected bladder cancers that had not spread to the muscle wall, earlier than cytology, potentially helping doctors to start treatment sooner and before symptoms appear.

A further benefit is that the new test distinguished cancer from urinary tract infections.

Professor Alain Ruffion, a researcher based at the University Hospital of Lyon’s Oncology Institute said: “The standard cytology test needs a doctor to look down a microscope to read the results, but the TERT test is read by a machine which is simpler, more accurate and available to use straightaway. While the TERT test costs slightly more than standard cytology, it is likely to become cheaper over time.”

“The fact that the test doesn’t react to urinary tract infections is very interesting because it shows that it is robust and unlikely to give misleading results.”

The discovery also suggests that further research is needed to understand more about the role TERT faults play in bladder cancer.

Anna Perman, senior science information manager at Cancer Research UK, said: “This promising study suggests a new and more accurate early warning system to detect whether bladder cancers are likely to return. Larger trials are now needed to see if this information could help more people survive by catching bladder cancer’s return at its earliest stage.”

ENDS

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References

Descotes et al. Non-invasive prediction of recurrence in bladder cancer by detecting somatic TERT promoter mutations in urine. British Journal of Cancer

http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017210a.html

Notes to Editor

*In the study, urine samples from 348 patients previously treated for Urothelial Bladder Cancer were analysed for TERT mutation as a marker for cancer recurrence and compared to the cytology/cystoscopy results. The patients were then monitored for recurrence.

This study was supported by the French Ministry of Health (PHRC National 2006).