Lifetime weight gain linked to oesophageal and stomach cancers

British Journal of Cancer

People who are overweight in their twenties and become obese later in life may be three times more likely to develop cancer of either the oesophagus (food pipe) or upper stomach, according to a study published in the British Journal of Cancer today (Wednesday).*

"This study highlights how weight gain over the course of our lives can increase the risk of developing these two cancer types, both of which have extremely poor survival." Dr Jessica Petrick

Those who first reported being overweight at the age of 20 were around 60-80** per cent more likely to develop these cancers in later life, compared to those who maintained a healthy weight throughout life.

People who gained more than three stone (20kg) during adulthood were also twice as likely to develop oesophageal cancer compared to people who had little weight change.

The study, led by researchers from the National Cancer Institute in Bethesda, US, pooled data from more than 400,000 people and analysed their reported height and weight at ages 20, 50, and at the time they gave the information. The researchers then followed them up to see which people developed cancer of either the oesophagus or upper stomach.

Study leader Dr Jessica Petrick, said: “This study highlights how weight gain over the course of our lives can increase the risk of developing these two cancer types, both of which have extremely poor survival.

“Carrying excess weight can trigger long-term reflux problems and heartburn that can lead to cancer. It can also change the levels of sex hormones, such as oestrogen and testosterone, cause levels of insulin to rise, and lead to inflammation, all of which are factors that have been associated with increased cancer risk.”

Around 5,600 people are diagnosed with oesophagus (food pipe) and upper stomach cancers in England every year. Being overweight or obese is the single biggest preventable cause of cancer in the UK after smoking and contributes to around 18,100 cases of cancer every year. In addition to cancers of the oesophagus and the upper stomach, it is linked to a range of other cancer types including bowel, breast, liver and pancreatic.***

Sarah Williams, health information manager at Cancer Research UK, said: “This study further highlights the importance of keeping a healthy weight throughout life to reduce the risk of developing these cancers. Small steps like taking the stairs more often, keeping an eye on portion sizes and switching to sugar-free drinks are simple things we can all do to help keep a healthy weight.”

“Participants were asked to recall what they weighed at different ages. Memories aren’t always accurate over long periods of time, so it will be interesting to see if these findings are backed up by future studies looking at lifetime weight gain and cancer risk in real time.”

This study was funded by NIH Intramural Research Program, National Cancer Institute.

References

J. L. Petrick et al, Body Weight Trajectories and Risk of Esophageal and Gastirc Cardia Adenocarcinomas: A Pooled Analysis of NIH-AARP and PLCO Studies, British Journal of Cancer (2017), DOI: 10.1038/bjc.2017.29.

http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc201729a.html

Notes to Editor

** 62-76 %

*** Calculated by the Statistical Information Team at Cancer Research UK:

a) The estimated population attributable fractions overweight and obesity for cancer cases (ICD10 C00-C97, excl. C44) in the UK in 2011 using Parkin, D. M. & Boyd, L. Overweight and obesity-attributable cancer burden in the UK in 2010. Br J Cancer 2011;105 (S2):S6-S13.

b) Incidence based on the annual average number of new cases of adenomas and adenocarcinomas (ICDO3 M8140-M8380, behaviour codes 3 only) of the oesophagus (ICD10 C15) and cardia of the stomach (ICD10 C16.0) diagnosed between 2012-2014 in England. Please note that there may be further cases of adenomas and adenocarcinomas that have not been classified with the appropriate morphology coding within this dataset, therefore this figure could be an underestimate.