Promising drugs turn immune system on cancer

Cancer Research UK

Cancer Research UK scientists have shown that a class of experimental drug treatments already in clinical trials could also help the body’s immune system to fight cancer, according to a study published today (Thursday) in the journal Cell.*

"This exciting research reveals that by blocking FAK, we’ve now found a promising new way to help the immune system recognise the cancer and fight it." - Dr Alan Serrels

Scientists at the University of Edinburgh revealed that a protein called Focal Adhesion Kinase, or FAK – which is often overproduced in tumours - enables cancer cells to elude attacks by the immune system.

FAK usually sends signals to help healthy cells to grow and move around.

But the researchers discovered it plays a different role in cancer cells, changing the nature of the immune system so that it protects the cancer cells rather than destroying them.

They then showed that using an experimental FAK inhibitor** prevented this change in the immune system allowing the cancer cells to be treated as a threat.

This is the first time that FAK inhibitors have been shown to influence the immune system, and particularly whether or not it recognises and fights cancer. This provides an unexpected and exciting potential new use for existing FAK inhibitor drugs.

The research was carried out in mice with a form of skin cancer called squamous cell carcinoma, but is likely to also apply to other cancers. The results showed that tumours completely disappeared when the mice were given FAK inhibitors.

This research was funded by Cancer Research UK, European Research Council, and the Medical Research Council.

Dr Alan Serrels, one of the lead authors, at the Edinburgh Cancer Research UK Centre at the University of Edinburgh, said: “FAK is hi-jacked by cancer cells to protect them from the immune system. This exciting research reveals that by blocking FAK, we’ve now found a promising new way to help the immune system recognise the cancer and fight it.

“The drug in this study is already in early stage clinical trials and could potentially be an excellent complement to existing immunotherapy treatments. Because it works within tumour cells rather than influencing the immune cells directly, it could offer a way to reduce the side effects of treatments that harness the power of the immune system against cancer.”

Nell Barrie, senior science communications manager at Cancer Research UK, said: “This promising research suggests these drugs may be able to help the immune system to destroy cancer cells.

“Research to maximise the power of the immune system is a really exciting area that Cancer Research UK scientists are exploring in detail. This particular approach hasn’t yet been tested in people, but there are plans to now find out how it could benefit patients alongside other immunotherapy treatments.”

ENDS

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Notes to Editor

* Serrels et al. Nuclear FAK controls chemokine transcription, Tregs and evasion of anti-tumor immunity. Cell (2015)

** Fak inhibitor provided by Verastem.