HPV pushes oral cancer cases past 6,000 a year

Cancer Research UK

The number of oral cancer cases diagnosed each year in the UK has risen above 6,000 for the first time, new figures from Cancer Research UK show today.

A decade ago there were over 4,400 cases of oral cancer. Now the latest figures show this has risen to over 6,200. Around two thirds of cases are in men.

Oral cancer rates in the UK have risen by around a quarter in the last 10 years from around six to eight cases per 100,000 people.

Experts believe that infections with high-risk strains of the human papillomavirus (HPV) may be a key reason for the jump in cases of oral cancer.

HPV infections are common with up to eight out of 10 people in the UK infected at some point in their lives.

Infections are usually on the fingers, hands, mouth and genitals. Many strains of the virus cause infections that are harmless and get better on their own. Most people will never know they had the virus.

But a few strains of HPV are known as high-risk. If these strains persist they can lead to cell changes which could develop into cancer. One of these high-risk strains is HPV-16.

Richard Shaw, a Cancer Research UK expert in head and neck cancers, based at the Liverpool Cancer Research UK Centre, said: “We have seen a rapid increase in the number of HPV16-positive cases of oral cancer. We have also noticed that patients with HPV-related oral cancers tend to be younger, are less likely to be smokers and have better outcomes from treatment than those whose tumours show no evidence of HPV.

“This raises questions as to exactly how these cancers develop and why they only affect a small proportion of people who are exposed.

“As HPV-related cancers appear to behave quite differently, the Liverpool Cancer Research UK Centre is also involved in Cancer Research UK-funded clinical trials to improve treatments.”

Traditionally, the main risk factors for oral cancer have been tobacco and alcohol. Oral cancers tend to take at least a decade to develop so looking at lifestyles 20 to 30 years ago can help understand the rise in cases.

Over the last 30 years, smoking rates in Britain have more than halved.

And while figures show that the amount of alcohol bought in the UK over the last 20 years has increased by 7 per cent – this is unlikely to be a large enough increase to explain fully the rise in the rates of oral cancers.

Experts say this suggests other risk factors may be playing a role – in particular HPV.

There were particularly sharp rises in the incidence rates of cancers at the base of the tongue (almost 90 per cent increase) and the tonsil (around 70 per cent increase) – two areas of the mouth where cancers are more commonly HPV-related.

Sara Hiom, director of information at Cancer Research UK, said: “It’s worrying to see such a big rise in oral cancer rates. But like many other cancers, if oral cancer is caught early, there is a better chance of successful treatment.

“So it’s really important for people to know the signs and symptoms of oral cancer - mainly mouth ulcers that just won’t heal, any lumps or thickening in the mouth, lips or throat, or red or white patches in the mouth that won’t go away.

“It’s not just doctors who have a vital role to play. If you’re worried about any of these symptoms you can see your dentist as well.

“Dentists have an important role to play in spotting oral cancer early and encouraging their patients to take care of their mouths. So make sure you attend regular dental check-ups.”    

ENDS

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Notes to Editor

Oral cancer refers to cancers that start in the mouth – this includes lips, inside lining of the cheeks and lips, the front two-thirds of the tongue, base of tongue, tonsils, the gums, the floor of the mouth, the roof of the mouth (called the hard palate) and the area behind the wisdom teeth. It also includes the oropharynx – the part of the throat just behind the mouth – this is known as oropharyngeal cancer.

There were 5,905 cases of oral cancer in 2008 in the UK, latest figures for 2009 show 6,236 cases.

Rates are given as a three-year average for 1998-2000 and 2007-2009.

The incidence rate of oral cancers in the UK has risen by around a quarter (26 per cent) in the last 10 years from 6.5 to 8.2 per 100,000 people.

Cases in the base of the tongue have increased from 284 to 595, cases in the tonsil have increased from 573 to 1,052

According to the latest Cancer Research UK study into risk factors for cancer, HPV is thought to be related to approximately 480 (8 per cent) of all oral cancer cases diagnosed in 2010. Tobacco accounts for around 64 per cent of oral cancers while alcohol is linked to about 20 per cent.

(Parkin, D M et al., - The Fraction of Cancer Attributable to Lifestyle and Environmental Factors in the UK in 2010 (British Journal of Cancer 2011) doi:10.1038/bjc.2011.474)

Symptoms of mouth and oropharyngeal cancer

The two most common symptoms of mouth cancer are

  • An ulcer in the mouth that will not heal – 80 out of every 100 people with mouth cancer (80 per cent) have this symptom
  • Discomfort or pain in the mouth that will not go away

Other symptoms can include

  • A white or red patch in the mouth or throat that will not go away
  • A lump or thickening on the lip, or in the mouth or throat
  • Difficulty or pain with chewing or swallowing
  • A feeling that something is caught in the throat
  • Unusual bleeding or numbness in the mouth
  • Loose teeth for no apparent reason
  • Difficulty moving the jaw
  • Speech problems
  • A lump in the neck
  • Weight loss
  • Bad breath (halitosis)

Less serious conditions than cancer may cause many of these symptoms. But it is important that you report any of these symptoms to your doctor or dentist.

Cancer Research UK works to raise symptom awareness, and encourage and enable people to go visit their doctor as soon as their notice anything unusual for their bodies.