Scientists predict three quarters of children with leukaemia will be cured

Cancer Research UK

Around three-quarters of children diagnosed with leukaemia today will be cured of their disease, according to research published in the British Journal of Cancer* today (Wednesday).

Scientists have developed a formal method for estimating the number of children diagnosed with leukaemia in the UK who are cured - meaning they have no greater risk of dying prematurely than children who never had leukaemia.

The cure rate has increased from 25 per cent in the early 1970s to 68 per cent in the early 1990s - and this figure is predicted to rise to 73 per cent for children diagnosed more recently.

The success of leukaemia treatment has previously been judged on five-year survival rates, which increased from 33 per cent to 79 per cent during 1971-2000. For some types of leukaemia, five-year survival is as high as 83 per cent.

The team examined how survival has changed over the years and they defined 'cure' as the point when the life expectancy of children diagnosed with leukaemia returned to normal for their age and sex.

First author Dr Anjali Shah, from the London School of Hygiene and Tropical Medicine, whose study was funded by charity CHILDREN with LEUKAEMIA said: "It's great that children diagnosed with leukaemia can be told that the numbers cured of this terrible disease are increasing.

"We think the substantial increase in survival and 'cure' is largely due to improvements in treatment and care, which have come about thanks to international research collaboration and well-organised, multi-disciplinary trials - many of which have been led by researchers in Britain. Some survivors still experience adverse effects years after the end of treatment, which emphasises the need for long-term medical surveillance of these people."

The research is based on data from the National Registry of Childhood Tumours, which holds statistics on virtually all children under the age of 15 diagnosed with cancer in Great Britain.

Senior author Professor Michel Coleman, who leads the Cancer Research UK Cancer Survival Group at the London School of Hygiene and Tropical Medicine, said: "Our study suggests that the development of new treatments for leukaemia, combined with clinical trials to refine treatment strategies, has been effective in curing more children with leukaemia.

"But alongside the more intensive treatments for leukaemia that increase the chance of cure, we need to reduce the risk of longer-term adverse effects that children may suffer in later life, which can include recurrence of cancer in other parts of the body."

Edward Copisarow, chief executive of CHILDREN with LEUKEAMIA, said: "The research makes an important contribution to the way the success of childhood leukaemia treatment is evaluated. This is the first time that anyone has estimated childhood leukaemia cure trends over time. Estimating cure and determining for how long patients should be monitored is a valuable step beyond the arbitrary success measures of survival 5 or 10 years after diagnosis, because it provides a better sense of the long-term success we are having in fighting this disease."

Dr Lesley Walker, director of cancer information at Cancer Research UK, said: "Although the majority of children with leukaemia can be cured, around a third don't respond well to current treatments and our efforts must focus on finding new treatments so that every child can survive a diagnosis of this disease.

"We will also need to continue long-term monitoring of childhood leukaemia survivors to document any effects the treatment may have in later life. This will help doctors to improve treatments for future patients."

ENDS

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Notes to Editor

*Childhood leukaemia: long-term excess mortality and the proportion 'cured'. Shah et al. British Journal of Cancer. 2008. 99(1).

About Leukaemia

Around 1500 new cases of childhood cancer are diagnosed each year in the UK - a third of these cases are leukaemia. The risk of a child being diagnosed with cancer before the age of 15 is about one in 500. Over 80 per cent of children survive for at least five years from a diagnosis of the most common type of childhood leukaemia - acute lymphoblastic leukaemia (ALL).

About the British Journal of Cancer (BJC)

The BJC is owned by the charity Cancer Research UK and its mission is to encourage communication of the very best cancer research from laboratories and clinics in all countries. Broad coverage, its editorial independence and consistent high standards have made BJC one of the world's premier general cancer journals.

About CHILDREN with LEUKAEMIA

CHILDREN with LEUKAEMIA is the UK's leading charity dedicated to the conquest of childhood leukaemia through pioneering research, new treatment and support of leukaemic children and their families. For more information on how to support CHILDREN with LEUKAEMIA call 020 7404 0808 or visit the CHILDREN with LEUKAEMIA homepage.

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