Protein could be crucial to spreading breast cancer says study

In collaboration with the Press Association

Scientists at the University of Manchester say that they may be closer to understanding how breast tumours spread after their studies showed that a previously known protein, called LPP, was involved in the process.

The study focused on breast cancer but researchers say that the finding could be relevant to other cancers.

"What we have identified is a new role for a protein called LPP," said lead researcher professor Andrew Sharrocks.

"Until now, this protein was only thought to function at the cell periphery but we have shown that it works in conjunction with another protein - PEA3 ? in the cell nucleus.

"PEA3 has already been implicated in the spread of breast cancer but we have found that the LPP molecule is essential for the correct function of PEA3."

"If we can target the LPP protein and stop it from working in cancerous cells, we have a possible new route to therapy."

The research is published in the journal Molecular and Cellular Biology.

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