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Risks and causes of penile cancer

Men and women discussing penile cancer

This page tells you about the risks and causes of penile cancer. We don’t know exactly what causes penile cancer. But there are some known risk factors. There is information below about


A quick guide to what's on this page

Risks and causes of penile cancer

Penile cancer is a rare cancer in Western countries including the UK. We don’t know exactly what causes penile cancer. But there are some known risk factors.  

Main risk factors

As with many cancers, it is more common in older people – 9 in 10 cases in the UK are in men 50 and over. You may have an increased risk if your father had penile cancer but as it is such a rare condition, this is still a very small risk.

The human papilloma virus (HPV) increases penile cancer risk. Around 5 out of 10 men with penile cancer have HPV infection.

Other risk factors

Other risk factors include smoking and having a weakened immune system. Factors that lower risk include being circumcised and having good personal hygiene.


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How common penile cancer is

Penile cancer is a rare cancer in Western countries. Around 600 men get diagnosed each year in the UK. That means that less than 1 in a 100 of new cancer cases in the UK are penile cancer. It is more common in men who live in Asia, Africa or South America.

The exact cause of penile cancer is not known but there are several risk factors. 


Human papilloma virus (HPV)

HPV is a common infection. It gets passed from one person to another by sexual contact. Around 8 out of 10 people (80%) in the UK get infected with the HPV virus at some time during their lifetime. For most people the virus causes no harm and goes away without treatment. But men with human papilloma virus have an increased risk of developing cancer of the penis. Some research studies have tried to find the link between penile cancer and HPV. Around 5 out of 10 (47%) men with penile cancer have evidence of HPV infection. HPV also increases the risk of cervical, anal, vulval and vaginal cancers.

HPV sometimes gets called the ‘wart virus’ because some types cause genital warts. There are over 100 types of HPV and each one has a number. The main types of HPV found in men with penile cancer are HPV 16 and 18. There may be other types too. HPV 16 and 18 don't usually cause genital warts. There is evidence that men with a history of genital warts have an increased risk of penile cancer.

In a Danish study, men who had never used condoms had more than double the risk of penile cancer. They were compared to men who had used condoms. This may be because condoms reduce the risk of HPV infection. Men who have two or more sexual partners before the age of 20 have a 4 to 5 increased risk of penile cancer. This may also be due to HPV infection.

Circumcision seems to reduce the risk of HPV infection of the penis.



It is rare for men below the age of 40 to get penile cancer. Most cases are in men aged over 50.



Men who smoke may be more likely to develop cancer of the penis. There are chemicals that cause cancer in cigarettes. Researchers believe that the chemicals may damage the DNA of cells in the penis and increase the risk of developing cancer.

Cells in the lining of the penis, called Langerhans cells, help fight disease. These cells don't work so well in smokers and can’t fight off viruses as well as they do in non smokers. So if you smoke and have a high risk type of HPV infection, you may be more at risk of penile cancer.


Having a weakened immune system

The immune system fights infection and diseases like cancer in the body. If you have a weakened immune system, you may be at higher risk of penile (and other cancers).  

HIV infection or AIDS may lower the immune system. Some drugs after an organ transplant may also weaken the immune system.


Uncircumcised men

Circumcision is a small operation to remove part, or all, of the foreskin. Uncircumcised men may sometimes find it difficult to draw back their foreskin. Doctors call this phimosis. Men with phimosis have a higher risk of penile cancer than other men. The reason for this is not clear. It may relate to other known risk factors including a buildup of secretions under the foreskin. Smegma is a cheese-like substance made up of dead skin cells that can build up under a tight foreskin. This can cause irritation and inflammation of the penis if it is not cleaned on a regular basis.

Male babies may have a circumcision at birth for social or religious reasons. The age of circumcision can affect the risk of penile cancer.

  • Men who are circumcised as babies appear to be less likely to get penile cancer.
  • Men who are circumcised in their teens seem to have some protection from penile cancer.
  • Circumcision in adulthood seems to make no difference to a man’s risk of penile cancer.

Remember that not being circumcised is only one risk factor for this type of cancer. Other risk factors such as smoking and HPV infection are more important.


Psoriasis treatment

Psoriasis (pronounced sore-eye-ah-sis) is a chronic skin condition. You can’t catch it from another person. It is sometimes treated with a combination of a drug called psoralen and light therapy (phototherapy). This treatment is known as PUVA and can also be a cancer treatment. Men who have had PUVA appear to have an increased risk of penile cancer.

giving men information to reduce risk


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Updated: 10 March 2016