Where this information about gestational trophoblastic tumours comes from | Cancer Research UK
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Where this information about gestational trophoblastic tumours comes from

Men and women discussing gestational trophoblastic tumours

This page tells you about the major sources of information that we use to put together this section of Cancer Research UK's patient information.


About our information

All our information is checked by cancer specialists and surgeons who specialise in treating cancer. The names of our specialist reviewers are at the end of this list. We also try to find patients to review all our sections. If you have had a gestational trophoblastic tumour, live in the UK, and would like to become a patient reviewer, you can write to us by clicking on contact us.



International Society for the study of Trophoblastic Disease (ISSTD) website 

Gestational Trophoblastic Disease a guide to management practices at Weston Park Hospital

Charing Cross Hospital (CXH) Trophoblast Disease Clinic Guide



Gestational Trophoblastic Disease 
3rd edition (April 2009)
Edited by B W Hancock, M J Seckl, R S Berkowitz and L A Cole

Cancer and its management (7th edition)
Tobias A and Hochhauser D
Wiley-Blackwell, 2015
ISBN: 978-1-118-46873-9

Cancer: Principles & Practice of Oncology (10th Edition) Gestational Trophoblastic Tumours chapter 
De Vita, V.T., Hellman, S. and Rosenberg S.A.
Lippincott, Williams and Wilkins, 2015
ISBN: 978-1-4511-9294-0


UK guidelines

Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up. Seckl M.J et al. Annals of Oncology 00: 1-12, 2013.

The Management of Gestational Trophoblastic Disease (3rd edition)
Royal College of Obstetricians and Gynaecologists
Guideline No 38, February 2010


Articles and reviews

Gestational trophoblastic disease. Seckl M, Sebire N and Berkowitz R. The Lancet, 2010. Vol 376: 717-729

EMA/CO for high-risk gestational trophoblastic neoplasia: good outcomes with induction low dose etoposide-cisplatin and genetic analysis. C Alifrangis and others. Journal of Clinical Oncology, Vol 31, No 2, Jan 2013.

Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia (Review). Alazzam M and others, The Cochrane Collaboration, 2014.

The Demographics of Molar pregnancies in England and Wales from 2000–2009. P Savage and others. The Journal of Reproductive Medicne, 2010 July–August, Vol 55; No 7–8.

First line chemotherapy in low risk gestational trophoblastic neoplasia. Alazzam M, Tidy J, Hancock BW, Osborne R. Cochrane Database of Systematic Reviews, 2009.

Practical issues in the management of low-risk gestational trophoblast tumours. Savage P, Seckl M and Short D. Journal of reproductive medicine, 2008 Oct; 53 (10): p774-80.

Diagnostic problems with Trophoblastic Lesions. Deavers et al, October 11, 2007. Archives of Pathology and Laboratory Medicine: Vol. 132, No. 2, pp 168-174.

Treatment of metastatic gestational trophoblastic neoplasia. El-Helw LM, Hancock BW. Lancet Oncology, 2007. Aug;8(8):715-24

Etoposide and Cisplatin/Etoposide, Methotrexate, and Actinomycin D (EMA) Chemotherapy for Patients With High-Risk Gestational Trophoblastic Tumors Refractory to EMA/Cyclophosphamide and Vincristine Chemotherapy and Patients Presenting With Metastatic Placental Site Trophoblastic Tumors. E S Newlands and others. Journal of Clinical Oncology, Vol 18, No 4 (February), 2000: pp 854-859.


Specialist reviewers

Professor Michael Seckl - Professor Medical Oncologist
Dr Matthew Winter  – Consultant Medical Oncologist
Dr Philip Savage  – Consultant Medical Oncologist
Ms Annie Hills – Nurse Counsellor in gestational trophoblastic tumours
Jan Everard  – Clinical Nurse Specialist
Linda Dayal  – Clinical Nurse Specialist



Dee McLean – MeDee Art, Medical Illustrations

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Updated: 23 June 2016