"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A trial looking at intensity modulated radiotherapy to treat prostate cancer (IMRT)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at intensity modulated radiotherapy to treat prostate cancer that has spread to the lymph glands in the pelvis. The pelvis is the area surrounded by your hip bones. This trial is supported by Cancer Research UK.
Intensity modulated radiotherapy (IMRT) is a way of targeting the areas of prostate cancer more exactly. This means that doctors are able to give a larger dose of radiotherapy to the cancer and a lower dose to surrounding healthy tissue. By doing this the side effects of radiotherapy may be reduced.
The aim of this trial is to see if IMRT can reduce the side effects of radiotherapy.
Who can enter
You can enter this trial if
- You have prostate cancer that has spread to the lymph glands in the
pelvis(your doctor can advise you about this)
You cannot enter this trial if
- Your doctors don’t think radiotherapy is the best treatment for you
- You have had radiotherapy to the pelvis before
- You have had surgery to the pelvis other than surgery to remove the prostate
- You have bowel disease
This is a phase 1 study. Everyone taking part will have 7½ weeks of radiotherapy to the prostate and the lymph glands in the pelvis.
Before you start radiotherapy you will have 6 to 12 months of hormone treatment. The hormone treatment will continue after the radiotherapy for a total of 3 years.
You will be asked to fill out a questionnaire
- Before starting radiotherapy
- Every 6 months for 2 years
- Then every year for 3 years
It will ask how you have been feeling and about any side effects that you have had. This is a called a quality of life questionnaire.
You will see the doctor and have some tests before you take part in this trial. These tests include
- Blood tests including PSA test
- Physical examination including rectal examination
- MRI scan or CT scan
You go to the hospital Monday to Friday each week for radiotherapy. You will do this for 7½ weeks. You will have more blood tests during your radiotherapy course.
After finishing radiotherapy you will have
- Regular appointments with your doctor
- A PSA test every 6 months for 5 years
- Rectal examination every 6 months for 2 years and then every year for 3 years
If your doctor thinks that your prostate cancer is growing again, you will have a CT scan or MRI scan, and a bone scan. Your doctor will then discuss treatment options with you.
The short term side effects of radiotherapy for prostate cancer include
The long term side effects of radiotherapy for prostate cancer include
- A feeling of wanting to strain, and bleeding from the back passage (proctitis)
- Difficulty passing urine
- Leaking urine (incontinence)
- Difficulty getting an erection (impotence)
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor David Dearnaley
Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer