A trial looking at intensity modulated radiotherapy to treat prostate cancer (IMRT)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer

Status:

Closed

Phase:

Phase 1

This trial is looking at intensity modulated radiotherapy to treat prostate cancer that has spread to the lymph glands in the pelvis. The pelvis is the area surrounded by your hip bones. This trial is supported by Cancer Research UK.

Doctors often treat prostate cancer with hormone therapy, surgery or external radiotherapy.

Intensity modulated radiotherapy (IMRT) is a way of targeting the areas of prostate cancer more exactly. This means that doctors are able to give a larger dose of radiotherapy to the cancer and a lower dose to surrounding healthy tissue. By doing this the side effects of radiotherapy may be reduced.

The aim of this trial is to see if IMRT can reduce the side effects of radiotherapy.

Who can enter

You can enter this trial if

  • You have prostate cancer that has spread to the lymph glands in the pelvis (your doctor can advise you about this)

You cannot enter this trial if

  • Your doctors don’t think radiotherapy is the best treatment for you
  • You have had radiotherapy to the pelvis before
  • You have had surgery to the pelvis other than surgery to remove the prostate
  • You have bowel disease

Trial design

This is a phase 1 study. Everyone taking part will have 7½ weeks of radiotherapy to the prostate and the lymph glands in the pelvis.

Before you start radiotherapy you will have 6 to 12 months of hormone treatment. The hormone treatment will continue after the radiotherapy for a total of 3 years.

You will be asked to fill out a questionnaire

  • Before starting radiotherapy
  • Every 6 months for 2 years
  • Then every year for 3 years

It will ask how you have been feeling and about any side effects that you have had. This is a called a quality of life questionnaire.

Hospital visits

You will see the doctor and have some tests before you take part in this trial. These tests include

You go to the hospital Monday to Friday each week for radiotherapy. You will do this for 7½ weeks. You will have more blood tests during your radiotherapy course.

After finishing radiotherapy you will have

  • Regular appointments with your doctor
  • A PSA test every 6 months for 5 years
  • Rectal examination every 6 months for 2 years and then every year for 3 years

If your doctor thinks that your prostate cancer is growing again, you will have a CT scan or MRI scan, and a bone scan. Your doctor will then discuss treatment options with you.

Side effects

The short term side effects of radiotherapy for prostate cancer include

The long term side effects of radiotherapy for prostate cancer include

  • A feeling of wanting to strain, and bleeding from the back passage (proctitis)
  • Difficulty passing urine
  • Leaking urine (incontinence)
  • Difficulty getting an erection (impotence)

There is more information about radiotherapy and hormone treatment for prostate cancer on CancerHelp UK.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor David Dearnaley

Supported by

Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 4030

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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