A trial looking at mini stem cell transplants for myelodysplastic syndrome and acute myeloid leukaemia (FB - ATG)

Cancer type:

Acute leukaemia
Acute myeloid leukaemia (AML)
Blood cancers
Myelodysplastic syndrome (MDS)




Phase 2

This trial was looking at reduced intensity stem cell transplants using thymoglobulin. It was for people who had poor risk myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).

If you can't have full stem cell transplant, you may have a mini transplant. The chemotherapy is less intensive, so they are sometimes called reduced intensity transplants.

Doctors already used the drugs fludarabine, busulphan and alemtuzumab (MabCampath) for mini transplants. In this trial they were looking at a different combination of drugs – fludarabine, busulphan and thymoglobulin.

Thymoglobulin is a drug that suppresses the immune system. This means that it could help stop the new stem cells from attacking parts of your body, a possible complication called graft versus host disease (GVHD).

The aims of this trial were to see

  • How well fludarabine, busulphan and thymoglobulin helped to stop MDS Open a glossary item and AML coming back after a mini transplant
  • What the side effects were

Summary of results

This trial was never finished so there are no results available. The researchers were unable to collect data from enough patients.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Ghulam J Mufti

Supported by

Experimental Cancer Medicine Centre (ECMC)
Genzyme Therapeutics
Kings College Hospital NHS Foundation Trust

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Last review date

CRUK internal database number:

Oracle - 2682

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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