Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A study looking at improving treatment for children with kidney cancer (IMPORT)
This study will collect information about children diagnosed with kidney cancer (renal cancer) such as Wilms’ tumour, to help with decisions about treatment in the future.
More about this trial
This study is for children, teenagers and young adults. We use the term 'you' in this summary, but of course if you are a parent, we are referring to your child.
The research team will collect information about scan results, diagnosis, cancer cells and how well treatments work for different people with kidney cancers such as Wilms' tumour. They will gather all this information together to try and find out why treatments work for some people and not others.
They will remove any details that would mean people taking part can be identified, and will put the rest of the information into a computer programme called P-medicine. They hope that this programme will help doctors decide which treatment is best.
Being part of this study won’t affect the treatment you have - you will have the standard treatment for your cancer. You won’t have any direct benefit from taking part in this study, but it might help doctors decide how to treat children with kidney cancer in the future.
The aim of this study is to improve treatment for children with kidney cancer.
Who can enter
You may be able to enter this trial if all of the following apply.
- You are a child, teenager or young adult with kidney cancer
- You have been diagnosed or treated at one of the Children’s Cancer and Leukaemia Group (CCLG) centres
- You agree that the research team can use samples of your cancer, blood and urine as part of the research project
If you join this study you will have the standard treatment for your type of cancer.
The research team will collect information about your diagnosis, the treatment you have and how well the treatment works. They will also look at samples of your cancer, blood and urine for any changes in genetic material (DNA) or proteins.
There is a small possibility that the research team will find a change (mutation) in one of your genes that they think caused your kidney cancer. If this happens, they will let your own cancer doctor know so he or she can discuss it with you in more detail.
They will put all the information they gather into a computer database called P-medicine. This information will be anonymous - no one will be able to identify you. They hope to use the information in the database to design a computer programme to help diagnosis and treatment in the future.
You will go to the hospital regularly as part of your treatment for kidney cancer. You won’t have to make any extra trips as part of this trial.
The samples the research team use will be samples that are taken as part of your diagnosis or routine treatment. You won’t need any extra tests, but you will need to give slightly larger blood and urine samples than if you were not taking part in the trial.
As there are no treatments or extra tests as part of this study, there are no direct side effects.
There will be side effects from the treatment you have for kidney cancer. The treatment you have will depend on the type and stage of your cancer, your doctor will tell you more about this.
How to join a clinical trial
Professor K Pritchard-Jones
Cancer Research UK
Children's Cancer and Leukaemia Group (CCLG)
Experimental Cancer Medicine Centre (ECMC)
Great Ormond Street Hospital for Children NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University College London
Institute of Child Health