A trial of ONY-P1 vaccine for prostate cancer that is not responding to hormone therapy

Cancer type:

Prostate cancer

Status:

Results

Phase:

Phase 2

This trial was looking at a vaccine for prostate cancer that is not responding to hormone therapy (hormone refractory prostate cancer).

Doctors often use hormone therapy to treat prostate cancer. But the cancer may stop responding to this treatment and the PSA level in the blood starts to rise.

Researchers are looking for new prostate cancer treatments that will help men who are no longer responding to hormone therapy. This trial was very early research into vaccine treatment. The aims of the trial were to

  • Find out more about how the immune system responds to the vaccine
  • See how the vaccine affects the PSA level in the blood
  • Learn more about the side effects

Summary of results

The trial team learnt more about how the immune system responds to the vaccine. They also found that in some men, the vaccine slowed down the speed at which their PSA level was rising. (In other words, it carried on going up, but more slowly than it had been).

  • The trial recruited 26 men who had been having hormone therapy for prostate cancer, but had a rising PSA
  • In 11 men, the rate of rise in PSA slowed down
  • About half the men had a reaction at the injection site, but there were no serious side effects

The researchers published these results in 2005. At that time, they compared their results with recent studies of other experimental treatments for men with prostate cancer no longer responding to hormone therapy. They found that on average, it took longer for the cancer to start growing again in men who had the vaccine than in men who had other types of treatment.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Hardev Pandha

Supported by

Onyvax Ltd

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle - 118

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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