A trial looking at vinflunine for advanced bladder cancer

Cancer type:

Bladder cancer
Transitional cell cancer

Status:

Results

Phase:

Phase 2

This trial was looking at a new chemotherapy drug called vinflunine to treat advanced bladder cancer.

Doctors may use chemotherapy to treat transitional cell bladder cancer that has spread. In this trial, the researchers wanted to see if vinflunine helps people with advanced transitional cell bladder cancer that has come back or got bigger after treatment with platinum drug chemotherapy.

The aims of the trial were

  • To find out how well vinflunine works for treating advanced transitional cell bladder cancer
  • To learn more about the side effects

Summary of results

From their analysis of results in 2006, the research team say that vinflunine can help people with advanced transitional cell cancer, without causing too many serious side effects.

The trial recruited 51 people. Everybody taking part had vinflunine at least once. The average number of treatments was 4.

  • In 9 people the cancer slowed or stopped growing - researchers call this partial response
  • In 25 people the cancer remained the same - researchers call this stable disease
  • In 14 people the cancer continued to grow
  • The researchers did not have results for 3 people

The main side effects were a drop in the number of blood cells and constipation, each of which affected about 2 thirds of people.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Nick James

Supported by

Pierre Fabre Medicament

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 170

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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