"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A trial of Zevalin as initial treatment for follicular lymphoma (FIZZ)
This trial looked at a drug called 90Y ibritumomab tiuxetan (Zevalin) as a first treatment for follicular lymphoma.
Follicular lymphoma is a common type of non Hodgkin lymphoma (NHL). If you have no symptoms or enlarged lymph glands when you are diagnosed, your doctor may decide to keep a close eye on you. You may hear this called ‘watch and wait’. But if you are having symptoms and other signs such as rapidly enlarging large glands, your doctor will want you to start treatment.
Zevalin is a ‘radio labelled’ monoclonal antibody. This means that it has a radioactive molecule called yttrium 90 attached to it. The antibody targets a protein called CD20 on the surface of the lymphoma cells and the radioactive yttrium kills them.
We know from research that Zevalin works well for people who have lymphoma that had come back after treatment.
The aims of this trial were to find out
- How well Zevalin worked as an initial treatment for follicular lymphoma
- About the side effects
Summary of results
The trial team found that Zevalin worked well as an initial treatment for newly diagnosed follicular lymphoma.
This was an international phase 2 trial. Everyone was to have 2 doses of Zevalin. Of the 74 people recruited, 72 had their first dose of Zevalin. 55 of the 72 people had both doses of Zevalin. Some people didn't have the 2nd dose for safety reasons .
Overall for 67 people their lymphoma responded to treatment. Of these 67 people, 45 had no sign of lymphoma - this is called a
The most common side effect of Zevalin was a drop in blood cells.
The trial team concluded that Zevalin worked well as a first treatment for follicular lymphoma.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Tim Illidge
Experimental Cancer Medicine Centre (ECMC)
The Christie NHS Foundation Trust