A trial of triamcinolone with hormone therapy for prostate cancer (TRICREST)

Cancer type:

Prostate cancer




Phase 2

This study is looking at a steroid drug called triamcinolone (pronounced try-am-sin-o-lone) for prostate cancer that has stopped responding to hormone therapy.

More about this trial

Doctors can treat prostate cancer with hormone therapy. But after some time, the cancer may stop responding to hormone treatment and start to grow again. Doctors call this hormone refractory prostate cancer or castration resistant prostate cancer.

In this situation, you may have steroids. In this trial, researchers are looking at a steroid drug called triamcinolone. The men taking part have triamcinolone alongside hormone therapy.

The aim of the trial is to see if triamcinolone helps men who have prostate cancer that is no longer responding to hormone therapy.

Who can enter

You may be able to enter this trial if you

You cannot enter this trial if you

If you have diabetes Open a glossary item, triamcinolone may upset your blood sugar balance. To be able to take part in this study, it must be possible to control this by adjusting your diabetes medication.

Trial design

This is a phase 2 trial. Everybody taking part has triamcinolone.

The first time you have triamcinolone, you have 2 injections. After that you have 1 injection each time. A member of the trial team will give the injections into the muscle in your bottom. Within a week of having the first injections, they will phone you to see how you are and ask if you’ve had any side effects.

You then have an injection once every 4 weeks. You also have a hormone therapy injections such as Zoladex or Prostap once a month, or once every 3 months.

The trial team will check the level of PSA in your blood after 12 weeks of treatment. If the level is falling, you carry on having triamcinolone.

As long as you don’t have bad side effects, you can carry on having the trial treatment until your prostate cancer starts to grow again.

The trial team will ask you to fill out a questionnaire when you join the trial, and then every month. The questionnaire will ask about side effects and how you’ve been feeling.  This is called a quality of life study.

The trial team will ask your permission to take an extra blood sample to study your genes and other substances in your blood. You don’t have to give this sample for research if you don’t want to. You can still take part in the main trial.

Hospital visits

You see the trial team and have some tests before you start the trial treatment. The tests include

You go to hospital once a month to have the triamcinolone injections. You can have your hormone therapy injections at your GP surgery

During the trial, you have regular blood tests and a bone scan every 12 weeks. At different times during your treatment, the trial team will ask you to keep all the urine you pass in a 24 hour period.

Side effects

The side effects of triamcinolone include

  • Mood changes
  • Stomach problems, indigestion or bloating
  • Increased appetite and weight gain
  • Feeling weak or tired
  • Increased risk of infection and wounds being slow to heal
  • Water retention
  • Diabetes
  • Skin problems such as thinning of the skin, bruising, rash, redness, itching or itchy raised lumps (hives)
  • Increased hair growth and sweating or flushing
  • Eye problems such as cataracts
  • Anxiety and problems sleeping
  • Thinning of your bones and muscle wasting

Rarely, people can have severe reaction to steroids. If you take steroids for a few months, you may notice weakness of your arms and legs and develop a rounder face.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Jonathan Shamash

Supported by

Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Orchid Cancer Charity

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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