Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A trial looking at radiotherapy after surgery for people with non small cell lung cancer (LungART)
This is a trial looking at radiotherapy for people with non small cell lung cancer. The trial is supported by Cancer Research UK.
Sadly the cancer can start to grow again and then be more difficult to treat. Doctors want to find out if radiotherapy to the chest after surgery can help to stop the cancer from starting to grow again.
Doctors know from research that radiotherapy can help people with non small cell lung cancer. Now with modern radiotherapy doctors want to find out more.
The aims of this trial are to find out
- If radiotherapy after surgery to remove NSCLC can help stop the cancer from coming back
- More about the side effects of radiotherapy after lung cancer surgery
Who can enter
You may be able to enter this trial if you
- Have non small cell lung cancer (NSCLC) that has been removed with surgery
- Have or have not had chemotherapy before or after your surgery (or both)
- Are well enough to have radiotherapy with the aim to cure
- Are well enough to be up and about for at least half the day, can look after yourself but are not necessarily able to work (performance status of 0, 1 or 2)
- Have satisfactory breathing test results (
lung function tests)
- Are willing to use reliable contraception if there is any chance that you or your partner could become pregnant
- Are at least 18 years old
You cannot enter this trial if you
- Have lung cancer that has spread (
- Have fluid around your heart or in your lungs that is causing you problems
- Have cancer that grew during chemotherapy
- Have already had radiotherapy to your chest
- Need chemotherapy with your radiotherapy
- Have lost more than a tenth (10%) of your body weight in the last 6 months
- Have any health problems that are a cause for concern
- Have heart problems that are a cause for concern
- Have had any other cancer, apart from carcinoma in situ of the cervix or non melanoma skin cancer that was successfully treated at least 5 years ago
- Are pregnant or breastfeeding
This trial will recruit 700 people from the UK and Europe. This is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
Both groups have surgery to remove their lung cancer.
Group 1 will have between 27 and 30 doses (
If you agree to take part in this study, the researchers will ask for a sample of tissue taken when you had surgery to remove your cancer. The researchers will also ask for an extra blood sample. If you do not want to give tissue or blood samples for this study, you don’t have to. You can still take part in the study.
You will see the doctors and have some tests before you start treatment. The tests include
- Blood tests
- Physical examination
- CT scan
- CT or MRI scan of the brain
- Breathing tests (
lung function tests)
- Heart ultrasound (
If you are in group 1 you will visit the hospital every day for your radiotherapy.
Everyone in the trial sees the trial doctors after 3 months and 6 months. They then see the doctors and have a CT scan
- 6 monthly for 3 years
- Then once a year for 2 years
You will also have breathing tests and a heart ultrasound (echocardiogram) once a year for 5 years.
You may have side effects from radiotherapy to the chest. The most common are
- Chest pain for up to 24 hours after your first treatment (fraction) which will go away
- Pain on swallowing
- Shortness of breath - this can start towards the end of your radiotherapy or after radiotherapy has finished and may last for up to 6 weeks
- Reddening and soreness of the skin in the treatment area
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Corinne Faivre-Finn
Cancer Research UK
European Organisation for Research and Treatment of Cancer (EORTC)
Experimental Cancer Medicine Centre (ECMC)
Institut de Cancerologie Gustave Roussy (IGR)
NIHR Clinical Research Network: Cancer
The Christie NHS Foundation Trust