A trial looking at radiotherapy after surgery for people with non small cell lung cancer (LungART)

Cancer type:

Lung cancer
Non small cell lung cancer




Phase 3

This is a trial looking at radiotherapy for people with non small cell lung cancer. The trial is supported by Cancer Research UK.

Doctors usually treat non small cell lung cancer (NSCLC) with surgery. Sometimes you may also have chemotherapy.

Sadly the cancer can start to grow again and then be more difficult to treat. Doctors want to find out if radiotherapy to the chest after surgery can help to stop the cancer from starting to grow again.

Doctors know from research that radiotherapy can help people with non small cell lung cancer. Now with modern radiotherapy doctors want to find out more.

The aims of this trial are to find out

  • If radiotherapy after surgery to remove NSCLC can help stop the cancer from coming back
  • More about the side effects of radiotherapy after lung cancer surgery

Who can enter

You may be able to enter this trial if you

  • Have non small cell lung cancer (NSCLC) that has been removed with surgery
  • Have or have not had chemotherapy before or after your surgery (or both)
  • Are well enough to have radiotherapy with the aim to cure
  • Are well enough to be up and about for at least half the day, can look after yourself but are not necessarily able to work (performance status of 0, 1 or 2)
  • Have satisfactory breathing test results (lung function tests Open a glossary item)
  • Are willing to use reliable contraception if there is any chance that you or your partner could become pregnant
  • Are at least 18 years old

You cannot enter this trial if you

  • Have lung cancer that has spread (metastases Open a glossary item)
  • Have fluid around your heart or in your lungs that is causing you problems
  • Have cancer that grew during chemotherapy
  • Have already had radiotherapy to your chest
  • Need chemotherapy with your radiotherapy
  • Have lost more than a tenth (10%) of your body weight in the last 6 months
  • Have any health problems that are a cause for concern
  • Have heart problems that are a cause for concern
  • Have had any other cancer, apart from carcinoma in situ of the cervix or non melanoma skin cancer that was successfully treated at least 5 years ago
  • Are pregnant or breastfeeding

Trial design

This trial will recruit 700 people from the UK and Europe. This is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

Both groups have surgery to remove their lung cancer.

Group 1 will have between 27 and 30 doses (fractions Open a glossary item) of radiotherapy to the chest.  You have one fraction each day, from Monday to Friday. So this takes between 5½ and 6 weeks in all. Group 2 do not have radiotherapy.

If you agree to take part in this study, the researchers will ask for a sample of tissue taken when you had surgery to remove your cancer. The researchers will also ask for an extra blood sample. If you do not want to give tissue or blood samples for this study, you don’t have to. You can still take part in the study.

Hospital visits

You will see the doctors and have some tests before you start treatment. The tests include

  • Blood tests
  • Physical examination
  • CT scan
  • CT or MRI scan of the brain
  • Breathing tests (lung function tests Open a glossary item)
  • Heart ultrasound (echocardiogram Open a glossary item)

If you are in group 1 you will visit the hospital every day for your radiotherapy.

Everyone in the trial sees the trial doctors after 3 months and 6 months. They then see the doctors and have a CT scan

  • 6 monthly for 3 years
  • Then once a year for 2 years

You will also have breathing tests and a heart ultrasound (echocardiogram) once a year for 5 years.

Side effects

You may have side effects from radiotherapy to the chest. The most common are

We have more information about side effects of radiotherapy to the chest in our radiotherapy section.


Newcastle upon Tyne

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Corinne Faivre-Finn

Supported by

Cancer Research UK
European Organisation for Research and Treatment of Cancer (EORTC)
Experimental Cancer Medicine Centre (ECMC)
Institut de Cancerologie Gustave Roussy (IGR)
NIHR Clinical Research Network: Cancer
The Christie NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUK/11/052.

We have more information about the work of Professor Corinne Faivre-Finn.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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