A trial of a new vaccine to treat throat cancer caused by a virus called human papillomavirus (REALISTIC)

Cancer type:

Head and neck cancers
Mouth (oral) cancer




Phase 1

This trial looked at a new vaccine called ADXS11 001. Researchers wanted to see if it was safe to use and could boost the immune system of people who had cancer of the part of the throat just behind the mouth (oropharyngeal cancer). This trial was supported by Cancer Research UK.

More about this trial

Some oropharyngeal cancers are caused by the human papilloma virus Open a glossary item (HPV). The vaccine ADXS11 001 was designed to boost the immune system of people with oropharyngeal cancer caused by HPV.

The vaccine was so new that the researchers didn’t know if it would work. So they needed to test it in a small number of people.

The main aims of this trial were to see if ADXS11 001 was safe to use and if it had an effect on the immune system.

Summary of results

This trial closed early after one person had developed a serious infection caused by the vaccine and the company who makes the vaccine decided not to continue supplying it for the study. 

We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Terence Jones

Supported by

Aintree University Hospitals NHS Foundation Trust
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Liverpool

Other information

This is Cancer Research UK trial number CRUK/10/010

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 4151

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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