A trial looking at MRI scans to pick up early signs of prostate cancer pressing on the spine (PROMPTS)

Cancer type:

Prostate cancer

Status:

Open

This trial is looking at using magnetic resonance imaging (MRI) to pick up early signs that prostate cancer is starting to press on the spine. This trial is supported by Cancer Research UK.

Sometimes prostate cancer can spread to the backbone (spine). This can cause pressure on the long bundle of nerves in the backbone (the spinal cord). Doctors call this spinal cord compression. The symptoms of spinal cord compression include pain and numbness. People with spinal cord compression need to have treatment quickly to relieve the pressure.

Doctors often use an MRI scan to confirm any symptoms of spinal cord compression. The researchers think that MRI scans may be used to find early signs of spinal cord compression before symptoms happen. This means treatment can start earlier, which may prevent the most severe symptoms.

The aim of this trial is to see if MRI scans can be used to find early signs of spinal cord compression before you have any symptoms.

Who can enter

You may be able to enter this trial if

You cannot enter this trial if

  • Your cancer has spread to your brain
  • You are taking daily painkillers for back pain caused by your cancer spread
  • You already have spinal cord compression or any other nerve damage
  • You have had radiotherapy or surgery to treat or prevent spinal cord compression – if you had radiotherapy to relieve pain in your spine caused by your cancer spread and now have no symptoms you may take part in this trial
  • You have had an MRI scan of your spine in the past year
  • You have had another cancer in the past 5 years apart from basal cell Open a glossary item carcinoma and early bladder cancer that is not likely to spread (low grade)
  • You are not able to have an MRI scan because for example you have a pacemaker or other metal in your body, or you cannot lie flat for at least 1 hour

Trial design

This is a phase 3 trial. It will recruit 541 men. It is a randomised trial. The people taking part are put into 1 of 2 groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

The men in group 1 will continue to be seen as usual. If you develop signs or symptoms of spinal cord compression you will receive treatment.

The men in group 2 will have a MRI scan. If this shows early signs of spinal cord compression you will have treatment. You then have a MRI scan every 6 months. If the scan doesn’t show signs of spinal cord compression you will see your doctor as usual.

PROMPTS trial diagram

The trial team will ask you to fill out a questionnaire when you agree to take part in this trial and then every 3 months for 3 years. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.

If you develop early signs of spinal cord compression the team will ask you to fill out another questionnaire about 3 months after your treatment.

Hospital visits

You see the doctor to have some tests before taking part in this trial. These tests include

  • A physical examination
  • Blood tests
  • PSA test

After agreeing to take part, the men in group 2 will have a MRI scan.

You see the doctor every 3 months for 2 years and then every 6 months for a year.

Side effects

MRI scan is a safe test and the researchers don’t anticipate any side effects.

You can find more information about MRI scans in our cancer tests section.

Location

Barnstaple
Basingstoke
Belfast
Bournemouth
Bradford
Brighton
Bristol
Bury St Edmunds
Cardiff
Carmarthen
Chesterfield
Coventry
Dartford
Derby
Doncaster
Dundee
Exeter
Great Yarmouth
Guildford
Harrogate
Huddersfield
Ipswich
Keighley
Kent
Kidderminster
Kingston upon Thames
Lancaster
Leeds
Liverpool
London
Maidstone
Newcastle upon Tyne
Northwood
Norwich
Nuneaton
Poole
Redditch
Romford
Sheffield
Shrewsbury
Stevenage
Sutton
Taunton
Wakefield
Warwickshire
Weston Super Mare
Wirral
Worthing

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor David Dearnaley

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
The Royal Marsden NHS Foundation Trust

Other information

This is Cancer Research UK trial number CRUK/11/053.

Contact our cancer information nurses for other questions about cancer by:

Phone - 0808 800 4040

Last review date

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

Rate this page:

No votes yet
Thank you!
We've recently made some changes to the site, tell us what you think

Share this page