A trial looking at a different way of giving posaconazole to prevent fungal infection after treatment for some blood cancers

Cancer type:

Acute leukaemia
Acute myeloid leukaemia (AML)
Blood cancers
Chronic leukaemia
Chronic myeloid leukaemia (CML)
Leukaemia
Myelodysplastic syndrome (MDS)

Status:

Results

Phase:

Phase 1

This trial looked at giving posaconazole in a different way to prevent fungal infection after treatment for acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and chronic myeloid leukaemia (CML).  

More about this trial

Doctors can treat AML, MDS and CML with chemotherapy or a bone marrow or stem cell transplant. One of the side effects of both these treatments is a drop in white blood cells causing an increased risk of infection, including fungal infection.

Posaconazole is a drug that doctors use to treat or prevent fungal infection.  It is a liquid that you swallow. The researchers developed another form of posaconazole that you have as a drip into a vein Open a glossary item.  The researchers wanted to measure the level of posaconazole in the blood after having it through a drip. They did this by taking blood samples.

The aims of this trial were to find out the

  • Levels of posaconazole in the blood before and after having it through a drip
  • Side effects of having posaconazole through a drip
  • Levels of posaconazole in the blood after switching from having it as a drip to a liquid that is swallowed

Summary of results

Despite attempting to contact the trial team, we have not been able to have the results for this trial checked.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Samir Agrawal

Supported by

Merck, Sharp & Dohme
Schering Plough Research Institute

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Last review date

CRUK internal database number:

Oracle 9215

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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