A trial looking at treatment for children and teenagers with a primitive neuroectodermal tumour that has come back (PNET-CNS 2000 01)

Cancer type:

Brain (and spinal cord) tumours
Children's cancers




Phase 3

This trial looked at using high dose chemotherapy and a stem cell transplant for children who had a neuroectodermal tumour that had come back following treatment.

Primitive neuroectodermal tumour (PNET) is a group of brain cancers that mainly occur in children. Doctors treat PNETs in the brain with surgery, radiotherapy and chemotherapy. But sometimes these treatments don’t work very well and the cancer comes back.

This trial was for children and young people up to the age of 21. We use the term 'you' in this summary, but of course if you are a parent, we are referring to your child.

If you have a PNET in the brain that has come back, it is difficult to treat.

The researchers wanted to find out if high dose chemotherapy Open a glossary item could improve the treatment for children and young people with PNET in the brain that had come back.

Summary of results

The trial team found that high dose chemotherapy was of little benefit for children and young people with primitive neuroectodermal tumours (PNETs) in the brain that had come back.

This trial included 45 children and young people who had a PNET that had come back.  Of these, 40 had the most common type of PNET called a medulloblastoma and 5 had a rarer type called a supratentorial PNET.  Most of them had previously had radiotherapy.

In this study, the planned treatment was cyclophosphamide and surgery or radiotherapy if appropriate. If this got rid of all or most of the cancer (put it into complete or nearly complete remission), the children and young people taking part could go on to have high dose chemotherapy.

Of the 5 children who had supratentorial PNET

  • All 5 started cyclophosphamide chemotherapy
  • 4 had surgery before having cyclophosphamide
  • 1 went on to have high dose chemotherapy  and radiotherapy

Unfortunately all of their tumours continued to grow and sadly they died.

Of the 40 children with medulloblastoma

  • All had cyclophosphamide
  • 19 also had surgery
  • 22 went on to have high dose chemotherapy

The researchers found that the average length of time they lived was just over 1 and half years.

After an average follow up period of nearly 7 and half years, 37 children had sadly died. The trial team concluded there was little benefit in giving high dose chemotherapy to children whose primitive neuroectodermal tumour had come back.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Barry Pizer

Supported by

Bristol-Myers Squibb
Children's Cancer and Leukaemia Group (CCLG)
Chugai Pharma UK Ltd
National Institute for Health Research Cancer Research Network (NCRN)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 248

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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