A trial looking at treatment for advanced osteosarcoma

Cancer type:

Bone cancer
Sarcoma

Status:

Results

Phase:

Phase 2

This trial looked at pemetrexed (Alimta) for people with osteosarcoma that was locally advanced or had spread to another part of the body, and who had already had chemotherapy.

Osteosarcoma is a type of bone cancer. Doctors usually give chemotherapy to treat advanced osteosarcoma. But at some point, the cancer may start to grow again, and may spread to another part of the body. If this happens, doctors tend to give more chemotherapy, but it is not clear what the best drug is to use.

Doctors hoped that a chemotherapy drug called pemetrexed may have helped to slow down the growth of the cancer. Doctors already use pemetrexed to treat a cancer called mesothelioma. But they wanted to see if it could be used to treat other types of cancer.

The aims of this trial were to

  • Find out how well pemetrexed worked for osteosarcoma
  • Learn more about the side effects

Summary of results

The study team found that pemetrexed didn’t work as well as they hoped.   

This trial recruited 32 people. Everyone had pemetrexed.

When the researchers looked at how well the osteosarcoma had responded they found that in

  • 1 person it had shrunk – partial response
  • 15 people it had stayed the same – stable disease

Unfortunately after treatment one person died. This could have been due to a complication of the pemetrexed. But the researchers were not sure.  

The most common side effects reported were

The trial team concluded that pemetrexed was not as good a treatment for osteosarcoma as they had hoped for.

The researchers are continuing to follow up the people who took part in the trial to see how they are getting on. We will update this summary as more results become available.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed) but may not have been published in a medical journal.  The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Mayukh Das

Supported by

Eli Lilly and Company Limited
Experimental Cancer Medicine Centre (ECMC)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 3709

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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