A trial looking at the treatment of infection during chemotherapy (ORANGE)

Cancer type:

All cancer types




Phase 3

This trial was comparing treating infections during a course of chemotherapy at home and in hospital. The trial was supported by Cancer Research UK.

Chemotherapy can cause a drop in the number of white blood cells. This is called neutropenia Open a glossary item. It puts you at more risk of getting an infection. If you develop an infection during your chemotherapy treatment, this can make you more ill than you normally would be. You may have to go into hospital for treatment with antibiotics Open a glossary item.

An infection can make some people seriously ill. They may then need to have antibiotics directly into the bloodstream (intravenous antibiotics). But many people are at a low risk of becoming very unwell. They will probably have their antibiotic treatment as tablets.

This trial was looking at those people who had antibiotic tablets. Doctors were trying to find out if it was better for people to stay in hospital until the infection had completely gone. Or if it would be better to go home once you began to feel better and your temperature had come down.

The aims of the trial were to

  • Find out if it was possible to identify people who were at low risk of complications
  • See how well the antibiotic tablets worked
  • Find out how often people who had treatment at home needed to come back into hospital

Summary of results

This trial was never finished so there are no results available. The researchers were unable to recruit enough patients.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr E Marshall

Supported by

Cancer Research UK
Clatterbridge Cancer Centre NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Birmingham

Other information

This is Cancer Research UK trial number CRUK/06/017.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

Rate this page:

No votes yet
Thank you!
We've recently made some changes to the site, tell us what you think

Share this page