A trial looking at radiotherapy or endoscopic surgery for early stage cancer of the glottis (EaStER)

Cancer type:

Head and neck cancers
Laryngeal cancer

Status:

Results

Phase:

Pilot

This trial looked at whether endoscopic surgery was as good as radiotherapy at stopping early stage cancer of the glottis coming back. This trial was supported by Cancer Research UK.

More about this trial

The glottis is the area around the vocal cords. It is part of the larynx. Patients with cancer of the glottis (glottic cancer) often have radiotherapy or surgery.

Traditionally, surgery for glottic cancer is open surgery and involves making a cut in the skin. It can mean a lengthy recovery. Another option is to do the operation by passing a tube (an endoscope) through the mouth and into the throat. The surgeon then uses either surgical instruments or laser to remove the cancer. This is called endoscopic surgery, or endoscopic excision.

Open surgery is used less often in the UK now, and endoscopic surgery is becoming more popular. But no one has done a trial to show if endoscopic surgery is as good as radiotherapy. In this trial, some patients had  endoscopic surgery and some had radiotherapy. The results of both groups will be compared to find out if endoscopic surgery is as good as radiotherapy at stopping the cancer from coming back (recurring).

This trial also looked at voice quality to find out if there is any difference in people’s voices following these two treatments.

Summary of results

We have contacted the trial team who tell us they don’t expect to be making results available for this trial.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Martin Birchall

Supported by

Cancer Research UK
NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/04/024.

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Freephone 0808 800 4040

Last review date

CRUK internal database number:

538

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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