A trial looking at intraductal screening for women at moderate to high risk of developing breast cancer (RMNHS- 2278)

Cancer type:

Breast cancer

Status:

Results

Phase:

Phase 2

This trial was aiming to find out if the intraductal approach could be used to screen women at moderate to high risk of developing breast cancer.

More about this trial

In the UK, mammograms are used to screen women over 50 to pick up early signs of breast cancer. They are also used for younger women who are at a higher risk of developing this disease.

But mammograms are not very effective for some people. For example, younger women have more dense breast tissue, making it more difficult for a doctor to interpret the mammogram. A new way of screening that is being looked at is called the ‘intraductal approach’. This includes 3 tests

  • Nipple aspiration
  • Ductal Lavage
  • Duct endoscopy

These tests are used to get samples of fluid from the milk ducts. The breast cells in the ducts always produce a certain amount of fluid, even when the woman is not producing breast milk.

Researchers think that useful information can be gained from looking at this fluid closely. This is because the fluid is in direct contact with the cells lining the breast ducts and lobules and the lining of the breast ducts is the most common place where breast cancer develops. It is possible that looking at this fluid may pick up cancerous cells or help to decide a woman’s risk of developing breast cancer in the future.

Summary of results

By using the intraductal approach, the researchers were able to build up a bank of fluid taken from women's milk ducts. This may be used in breast cancer research in the future.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Mr Gui

Supported by

The Royal Marsden NHS Foundation Trust

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Last review date

CRUK internal database number:

Oracle 554

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Caroline took part in a clinical trial for breast cancer

“I had treatment last year and I want to give something back.”

Last reviewed:

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