A trial looking at hormone therapy with or without radiotherapy in locally advanced prostate cancer (PR07)

Cancer type:

Prostate cancer

Status:

Results

Phase:

Phase 3

This trial was comparing hormone therapy and radiotherapy together with hormone therapy alone for prostate cancer that had grown through the covering of the prostate gland (locally advanced prostate cancer).

Doctors often treated locally advanced prostate cancer with hormone therapy alone. The aim of this trial was to see if having a combination of both hormone therapy and radiotherapy helped men to live longer than having hormone therapy alone.

Summary of results

The trial team found that on average, men who had both hormone therapy and radiotherapy lived longer than men who had hormone therapy alone.

The trial recruited 1,205 men, including more than 800 in the UK.

  • 602 had hormone therapy alone
  • 603 had hormone therapy and radiotherapy

The researchers looked at how many men were still alive 7 years after treatment. They found this was

  • 407 who had hormone therapy alone
  • 458 who had hormone therapy and radiotherapy

Prostate cancer had come back in

  • 251 men who had hormone therapy alone
  • 95 men who had hormone therapy and radiotherapy

In 2012, the researchers presented their final analysis of the results. By then, they had followed up the men taking part for an average of 8 years and found that overall, adding radiotherapy to hormone therapy significantly reduced the risk of death.

Unfortunately, 465 of the men who took part in the trial had died.

  • 260 who had hormone therapy on its own
  • 205 who had hormone therapy and radiotherapy

The researchers found that 199 of the deaths were due to prostate cancer or its treatment - 134 in the hormone therapy group and 65 in the hormone therapy and radiotherapy group.

Men who had radiotherapy did have more side effects such as diarrhoea, but they were generally mild. 

The trial team concluded that men having both hormone therapy and radiotherapy have a significantly lower chance of dying from disease related causes than men having hormone therapy alone. They suggest that having a combination of hormone therapy and radiotherapy should now be standard treatment for locally advanced prostate cancer. 

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed) and published in a medical journal or presented at scientific conferences. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Malcolm Mason

Supported by

Medical Research Council (MRC)
National Institute for Health Research Cancer Research Network (NCRN)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 110

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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