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A trial of dinutuximab beta and interleukin-2 for neuroblastoma in children and young people (SIOPEN LTI)

Overview

Cancer types:

Children's cancers, Neuroblastoma

Status:

Results

Phase:

Phase 2

Details

This trial looked at dinutuximab beta with or without interleukin-2 for neuroblastoma. And at giving treatment over a longer period of time.

It was for children and young people whose cancer had come back after treatment. Or had continued to grow while having treatment.

The trial was supported by Cancer Research UK. It was open for people to join between 2012 and 2017. The team have published several results papers between 2018 and 2025. We hope to update this page if more results become available.

Recruitment start: 1 January 2012

Recruitment end: 31 July 2017

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Juliet Gray

Supported by

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

International Society of Paediatric Oncology European Neuroblastoma (SIOPEN) Group

NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/11/035.

Last reviewed: 03 Oct 2025

CRUK internal database number: 8781

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