"I am glad that taking part in a trial might help others on their own cancer journey.”
A trial looking at different ways of giving radiotherapy for children and young people with medulloblastoma (HIT - SIOP PNET 4) (CNS 2003 05)
This trial compared standard radiotherapy with hyperfractionated radiotherapy (HFRT) for children and young people with medulloblastoma. This trial was supported by Cancer Research UK.
This trial was for children from 4 years old and young people up to and including the age of 21. We use the term 'you' in this summary, but of course if you are a parent, we are referring to your child.
In some children, the medulloblastoma does not spread to the rest of the brain or spinal cord. Doctors call this ‘standard risk’. Treatment for standard risk medulloblastoma includes surgery to remove as much of the cancer as possible. But there may be cancer cells left behind. So children have radiotherapy and chemotherapy after surgery.
This trial tried to find the best way of giving radiotherapy to children with medulloblastoma. It compared the standard treatment of daily radiotherapy with hyperfractionated radiotherapy (HFRT). Children had HFRT twice a day instead of once. They had smaller doses, but the dose of radiotherapy overall was bigger. The researchers thought HFRT may kill more cancer cells than standard radiotherapy. The aim of the trial was to find out which method
- Was better at stopping the cancer from coming back
- Had the fewest side effects
Summary of results
The trial team found that hyperfractionated radiotherapy (HFRT) was no better than standard radiotherapy as part of treatment for medulloblastoma.
After an average follow up of 5 years, the researchers looked at the overall number of children still alive. For those who had standard radiotherapy it was 87 out of every 100 children (87%) and those who had HFRT it was 85 out of every 100 children (85%).
They also looked at the number of children who had no sign of their cancer after 5 years. For those who had standard radiotherapy, it was 77 out of every 100 children (77%) and for those who had HFRT it was 78 out of every 100 children (78%).
The researchers didn’t find any significant difference between the side effects of the 2 treatments.
The researchers concluded that hyperfractionated radiotherapy was no better than standard radiotherapy as part of treatment for medulloblastoma.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Prof Barry Pizer
Cancer Research UK
Cancer Research UK Children's Cancer Trials Team
University of Birmingham
National Institute for Health Research Cancer Research Network (NCRN)
This is Cancer Research UK trial number CRUK/03/012.