A trial looking at chemotherapy for Ewing’s sarcoma (rEECur)

Cancer type:

Children's cancers
Ewing's sarcoma
Sarcoma

Status:

Open

Phase:

Other

This trial is looking at 4 different types of chemotherapy to treat Ewing’s sarcoma that didn’t respond to treatment or has come back afterwards.

Ewing’s sarcoma is a type of cancer that mainly affects teenagers, young adults and children. This trial is for both adults and children.  We use the term 'you', but if you are a parent, we are referring to your child.

More about this trial

Doctors can treat Ewing’s sarcoma with surgery, chemotherapy or radiotherapy. If Ewing’s sarcoma doesn’t respond to these treatments, or comes back afterwards, there isn’t a standard treatment Open a glossary item.

In this trial, researchers are comparing 4 different types of chemotherapy that can be used to treat Ewing’s sarcoma that hasn’t responded to treatment, or has come back afterwards. The types of chemotherapy they are looking at are

The aim of the trial is to find out which treatment works best and which has the fewest side effects.

Who can enter

You may be able to join this trial if all of the following apply. You

  • Have Ewing’s sarcoma that didn’t respond to the treatment you had, or has come back afterwards
  • Are at least 4 years old, but under 50 years of age
  • Are well enough to have chemotherapy
  • Are willing to use reliable contraception during the trial and for up to a year afterwards if you are sexually active and there is any chance you or your partner could become pregnant.

You cannot join this trial if any of these apply. You

  • Have sarcoma cells in your bone marrow Open a glossary item that has caused a drop in the number of white blood cells called neutrophils Open a glossary item (the trial doctor can advise you about this)
  • Have had chemotherapy or an experimental drug in the last 2 weeks
  • Have had high dose chemotherapy that kills cells in your bone marrow in the last 8 weeks
  • Have had radiotherapy to treat your sarcoma in the last 6 weeks
  • Are pregnant or breastfeeding

Trial design

This is an international trial. The researchers need about 500 people to take part in the UK and other countries in Europe.

It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

You have one of the following

You have chemotherapy in 3 week periods called cycles of treatment. If you are in the group having ifosfamide, you will have 4 cycles of treatment. If you are in any of the other 3 groups, you will have 6 cycles. If your sarcoma responds well, your doctor may decide to give you more cycles of treatment.

If you are in the TC, IT or IFOS group, you have chemotherapy for 5 days in a row every 3 weeks.

If you are in the GD group, you have chemotherapy on one day in the first week and one day in the second week of each 3 week treatment cycle.

Before you start treatment, you may have a central line put in. A central line is a small plastic tube which goes under the skin and into a vein under your collar bone. It will stay in place until you finish treatment. This makes it easier to give treatment and take blood samples.

The trial team will ask you to fill out a questionnaire before you start treatment, after 2 cycles of treatment and after 4 cycles of treatment. The questionnaire will ask about side effects and how you’ve been feeling.  This is called a quality of life study.

The trial team may also ask you to have a PET-CT scan before starting chemotherapy, and again after 4 cycles of treatment. They want to find out if PET-CT scans are better than other types of scan at measuring how widespread the sarcoma is before and after treatment.

Hospital visits

You see the trial team and have some tests before you start treatment. The tests can include

Your doctor will decide which type of scan you need, depending on where the sarcoma is. You may also need to have a bone marrow test.

If you are in the group having ifosfamide, you will need to have a test to see how well your kidneys are working. This is called a GFR test Open a glossary item. You have the test again after 4 cycles of treatment.

You see the trial team and have blood tests regularly during treatment. You have another scan after the 2nd and 4th cycles of chemotherapy. If you have 6 cycles of treatment, you have another scan after the 6th cycle.

When you finish treatment, the trial team will check how you are getting on for up to 5 years. They can do this from information collected at your regular hospital appointments.

Side effects

The most common side effects of the chemotherapy drugs being tested in this trial include

The trial team will talk to you about all the possible side effects before you agree to take part.

We have more information about

Location

Aberdeen
Belfast
Birmingham
Bristol
Cambridge
Cardiff
Glasgow
Leeds
Leicester
Liverpool
London
Lothian
Manchester
Newcastle upon Tyne
Nottingham
Oxford
Sheffield
Sutton

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Martin McCabe

Supported by

European Commission’s FP7 health programme
University of Birmingham

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

11893

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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