A trial looking at chemotherapy after surgery for colorectal cancer (QUASAR 1)

Cancer type:

Bowel (colorectal) cancer
Colon cancer
Rectal cancer




Phase 3

This trial looked at adjuvant Open a glossary item chemotherapy for people who have bowel cancer (colorectal cancer) removed with surgery.

Surgery is usually the first treatment for bowel cancer. Some people also have chemotherapy. Doctors thought that this reduced the risk of the cancer coming back, but they were not sure.

The aim of this trial was to see if having drugs called fluorouracil and folinic acid Open a glossary item after surgery helped to stop stage 1, 2 or 3 colorectal cancer coming back after surgery.

Summary of results

The research team found that chemotherapy could reduce the risk of cancer coming back in people with stage 2 or 3 bowel cancer.

The trial recruited 3,239 people who had bowel cancer that had been completely removed with surgery. Most people taking part had stage 2 bowel cancer. Half the people had chemotherapy, the other half did not (the control group Open a glossary item).

When they did their analysis in 2007, the researchers found that cancer had come back in

  • 293 people in the chemotherapy group
  • 359 in the control group

People in the chemotherapy group had more diarrhoea, sickness, sore mouth, loss of appetite and fatigue than the control group, but only during the time they were having chemotherapy.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr David Kerr

Supported by

Cancer Research UK
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer

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Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 7

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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