A trial looking at monitoring early prostate cancer to decide whether or not treatment is needed

Cancer type:

Prostate cancer





This trial is looking at assessing men with early prostate cancer to see if their cancer grows before they decide whether or not to have treatment.

Doctors usually treat early prostate cancer with surgery or radiotherapy. But treatment for prostate cancer can have many side effects and sometimes prostate cancer can be very slow growing. So doctors may choose an approach called active surveillance before deciding whether or not to give treatment. This means that, before they give treatment, doctors will keep a close eye on (observe) the cancer to see if it grows.

The researchers in this trial want to find out what happens to the cancer when they observe instead of giving treatment straight away. They aim to find out

  • How many men will need treatment in the future because their cancer continues to grow
  • How many men will never need treatment because the cancer doesn’t grow

The men taking part will give blood and urine samples, and have MRI scans of their prostate. The doctors in this trial will use these to try and predict if the cancer will grow. The results of this trial may help doctors to improve treatment for prostate cancer in the future.

Please note - if you took part in this trial before July 2013 you will have had repeat biopsies as well as MRI scans.

Who can enter

You can enter this trial if you

Trial design

This trial will recruit 750 men who have prostate cancer that has not spread outside the prostate. All those taking part will have a PSA blood test every 6 months.

The researchers will store some of the blood samples in a blood bank and they may be used for future research.

You will also have an MRI scan of your prostate every 2 years.

If the results of any of your tests show that your cancer is starting to grow, the doctor will then discuss treatment options with you.

Hospital visits

Before you can enter the trial, the doctor will examine you and you will have some tests, including blood tests. You will also have to have an MRI scan of your lower tummy area (abdomen).

You will need to go to the hospital to see the doctor and to have your blood tests. You will also go to the hospital at least every 2 years to have an MRI scan of your prostate.

Side effects

There are no treatments in this trial. You may get a small bruise where your blood sample is taken.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr C. Parker

Supported by

Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
The Royal Marsden NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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