A trial looking at a drug called naptumomab estafenatox alongside interferon for advanced renal cell cancer

Cancer type:

Kidney cancer
Renal cell carcinoma

Status:

Results

Phase:

Phase 2/3

This trial was looking at a drug called naptumomab estafenatox (also known as ABR-217620) alongside interferon for a type of kidney cancer called renal cell cancer. It was for people who had renal cell cancer that could not be removed with surgery or had spread to another part of the body.

If renal cell cancer can’t be removed with surgery, or has spread to another part of the body, you may have biological therapy.

Interferon is a type of biological therapy that doctors can use. In this trial, researchers were looking at another type of biological therapy called naptumomab estafenatox.

Naptumomab estafenatox is made of 2 proteins. The first one recognises renal cancer cells. The second one stimulates the immune system to attack the cancer cells.

The aim of this trial was to see if people with advanced renal cell cancer who had a combination of naptumomab estafenatox and interferon lived longer than people who had interferon alone.

Summary of results

Overall, people who had naptumomab estafenatox and interferon didn’t live longer than people who had interferon alone.

The trial recruited 513 people who were put into groups by computer. Neither they, nor their doctors could decide which group they were in. This is called randomisation.

The people taking part had 1 of the following treatments

  • Naptumomab estafenatox and interferon
  • Interferon alone

The researchers looked at the average length of time people lived without any signs of their disease getting worse. Researchers call this progression free survival. They found that on average, progression free survival was just under 6 months for people in both groups.

They also looked at the length of time people lived overall. They call this overall survival. They found that on average, it was over 17 months for people in both groups.

But the researchers could see that in some patients, both progression free survival and overall survival were longer when people had the combination of both drugs. They suggest there should be more studies looking at naptumomab estafenatox with other drugs in certain sub groups of patients.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) but may not have been published in a medical journal.  The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Robert Hawkins

Supported by

Active Biotech AB

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Last review date

CRUK internal database number:

991

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

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"I am glad that taking part in a trial might help others on their own cancer journey.”

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